The ability of living cells, either adherent or suspended, to internalize nickel nanowires is demonstrated for MC3T3-E1, UMR106-tumour and Marrow-Stromal cells. Nanowires were produced by electrodeposition, 20 mum long and 200 nm in diameter. Cell separation and manipulation was achieved for the three cell types. Applied magnetic field successfully oriented the internalized nanowires but no cle...

Drug delivery system based on nanobiotechnology can improve the pharmacokinetics and therapeutic index of chemotherapeutic agents, which has revolutionized tumor therapy. Onivyde, also known as MM-398 or PEP02, is a nanoliposomal formulation of irinotecan which has demonstrated encouraging anticancer activity across a broad range of malignancies, including pancreatic cancer, esophago-gastric ca...

Modified nucleic acids have considerable potential in nanobiotechnology for the development of nanomedicines and new materials. Locked nucleic acid (LNA) is one of the most prominent nucleic acid analogues reported so far and we herein for the first time report the enzymatic incorporation of LNA-U and C5-ethynyl LNA-U nucleotides into oligonucleotides. Phusion High Fidelity and KOD DNA polymera...

Verónica Carrasco-Sánchez 1, Amalraj John 2, Adolfo Marican 2,3, Leonardo S. Santos 2,3 and V. Felipe Laurie 1,3,* 1 School of Agricultural Sciences, Universidad de Talca, Talca 3460000, Chile; [email protected] 2 Laboratory of Asymmetric Synthesis, Chemistry Institute of Natural Resources, Universidad de Talca, Talca 3460000, Chile; [email protected] (A.J.); [email protected] (A.M.); l...

The study and utilization of bionanomotors represents a rapid and progressing field of nanobiotechnology. Here, we demonstrate that poly(amidoamine) (PAMAM) dendrimers are capable of supporting heavy meromyosin dependent actin motility of similar quality to that observed using nitrocellulose, and that microcontact printing of PAMAM dendrimers can be exploited to produce tracks of active myosin ...

Nanocomposites of diphenylalanine (FF) and carbon based materials provide an opportunity to overcome drawbacks associated with using FF micro- and nanostructures in nanobiotechnology applications, in particular their poor structural stability in liquid solutions. In this study, FF/graphene oxide (GO) composites were found to self-assemble into layered micro- and nanostructures, which exhibited ...

for diaCEST agents; b) CEST contrast curves for representative salicylic acid (1) and anthranilic acid derivatives (2, 4, 11 and 12) using B1 = 3.6 μT, tsat = 3 s (25 mM , pH 7.1-7.4). Anthranilic Acid Analogues as Uncommonly Shifted HYdrogen bonded (U SHY) diamagnetic CEST (diaCEST) MRI Contrast Agents based on the N-H exchange Xiaolei Song, Xing Yang, Sangeeta Ray Banerjee, Martin G Pomper, a...

The oncogene c-Jun has been found to be up-regulated in a variety of cancers, including osteosarcoma. Doxorubicin is a frontline chemotherapeutic against osteosarcoma, but is limited by toxicity. DNAzymes are oligonucleotides capable of specific catalysis of target mRNA. A biocompatible c-Jun DNAzyme nanoparticle formulated from chitosan regressed the growth and metastasis of pre-established tu...

In sustained severe ischemia, reperfusion with oxygen carriers may result in ischemia-reperfusion injuries because of the release of damaging oxygen radicals. A nanobiotechnology-based polyhemogloin-calatase-superoxide dismutase can prevent this because the oxygen carrier, polyhemoglobin, is linked to antioxidant enzymes, catalase and superoxide dismutase. However, these antioxidant enzymes com...

Kevin A. Wepasnick , Billy A. Smith , Kaitlin E. Schrote , Hannah K. Wilson , Stephen R. Diegelmann , D. Howard Fairbrother a,d,e,* a Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States b Department of Chemistry, College of Notre Dame of Maryland, 4701 North Charles Street, Baltimore, MD 21210, United States c Department of Chemical a...