OBJECTIVE To identify genes whose expression is most characteristic of chronic rhinosinusitis and aspirin-sensitive asthma through genome-wide transcriptional profiling of nasal polyp tissue. STUDY DESIGN Prospective, controlled study conducted at a tertiary care institution. METHODS Thirty genome-wide expression microarrays were used to compare nasal polyp tissue from patients with chronic...

A sphenochoanal polyp is a soft tissue mass originating from the sphenoid sinus and extending to the posterior choanae via the sphenoethmoidal recess. Compared with common nasal polyposis and antrochoanal polyps, reports of sphenochoanal polyps in the English literature are relatively rare. In this report, a 12-year-old boy who presented with persistent left nasal obstruction and rhinorrhea was...

BACKGROUND Sinonasal angiomatous polyp (SAP) is a rare subtype of sinonasal polyp that might be misdiagnosed as a malignant lesion due to its clinical symptoms. METHODS We retrospectively enrolled the patients who were diagnosed with SAP in our hospital during 2008-2015. We analyzed the clinical symptoms, radiological findings, and pathological features of all patients diagnosed with SAP. R...

Malignant tumours of the nasal cavity are rare. Olfactory neuroblastomas (esthesioneuroblastomas) account for only 6% of these neoplasms. Fewer than 1,000 cases have been reported in the literature since this tumour was first described more than 75 years ago. A 13 year old girl presented with bleeding nasal polyp to ENT Department. She was operated as there were no signs of tumour the histopath...

although several treatments have been suggested for nasal polyposis, from medical to surgical, there is no standard guideline for the management of this disease. during recent years increasing attention has been directed toward the effects of macrolide antibiotics on chronic sinusitis and nasal polyposis. in this study,  the efficacy of clarithromycin on severe nasal polyposis were examined. in...

Objective: Nasal polyposis (NP) is defined as persistent inflammation of the sinonasal mucosa intractable to medical and surgical treatment. Activin-A, a pleiotropic cytokine in transforming growth factor-b (TGF-β) superfamily was shown orchestrate allergic asthma via suppression T helper-2 (Th2) cells, induction regulatory tissue repair. The purpose this study investigate role activin-A pathop...

Background: Nasal polyps are benign chronic inflammatory masses with epithelial tissues of the nasal mucosa and paranasal sinuses. The clinical diagnosis is made based on sinonasal symptoms for more than three months presence in cavity. classification histopathological structure divided into types, i.e., oedematous, eosinophilic polyps, seromucous polyps. This study aims to describe profile pat...

Myeloid Sarcoma (MS) is a tumor mass consisting of myeloblast with or without maturation occurring at an anatomical site other than the bone marrow. Incidence of MS ranges from 1-9% and is most commonly misdiagnosed as Non Hodgkins Lymphoma or poorly differentiated carcinoma. MS can occur in various sites but nasal cavity involvement is rare. Here we report acaseof MS presenting as nasal polyp ...

Resveratrol (RSV) has been shown to effectively suppress chronic rhinosinusitis with nasal polyps in a mouse model; however, when locally administered to the sinonasal cavity, bolus RSV is limited by low drug bioavailability owing to its low aqueous solubility and relatively rapid clearance from the administration site. To address this limitation, we propose mucoadhesive nanostructured micropar...

OBJECTIVES/HYPOTHESIS Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a disease process that is driven, in part, by intrinsic mucosal inflammation. Surgery plus continued medical therapy is commonly elected by medically recalcitrant, symptomatic patients. The objective was to evaluate the prevalence of nasal polyp recurrence up to 18 months after endoscopic sinus surgery (ESS) with cong...