Background Breast cancer remains the most common diagnosed in women worldwide. Aromatase inhibitors (AI) are employed for hormone sensitive disease mainly postmenopausal women. AI related bone loss (AIBL) is a known complication; although data regarding natural history real-world, long-term outcomes and role of active therapy fracture prevention sparse. Objectives Our aim was to determine real-...

Thrombotic disorders represent the major share of the various cardiovascular diseases, and significant progress has been made in the development of synthetic thrombin inhibitors as new anticoagulants. In addition to the development of highly potent and selective inhibitors with improved safety and suitable half-life, several allosteric inhibitors have been designed and synthesized, that did not...

A new CYP26A1 homology model was built based on the crystal structure of cyanobacterial CYP120A1. The model quality was examined for stereochemical accuracy, folding reliability, and absolute quality using a variety of different bioinformatics tools. Furthermore, the docking capabilities of the model were assessed by docking of the natural substrate all-trans-retinoic acid (atRA), and a group o...