In addition to its effect on Trichomonas vaginalis, metronidazole has also been found to be active against the organisms causing Vincent's gingivitis. This has raised the question of its possible action on Treponema pallidum, although Scott-Gray and Murrell (1961) found that a short course of 1-8 g. given over 48 hours did not affect a case of primary syphilis, and Yobs, Clark, and Schroeter (1...

It is estimated that more than 2-4% of hospital admissions are related to drug induced reactions. There is an ever expanding list of medications linked to pathologic reactions in the oral and perioral region. Several patterns of diseases have been identified, and these can assist the clinician in determining a possible cause and effect relationship with a particular or a group of drugs. The mec...

Denture stomatitis is a prevalent and longstanding problem in complete denture wearers. Post denture placement produces significant changes in the oral environment that may have an adverse effect on the integrity of the oral tissues. Mucosal changes could result from a mechanical irritation by the dentures, traumatic occlusion, an accumulation of microbial plaque, fungal infection or, a toxic o...

Buruli ulcer (BU), caused by Mycobacterium ulcerans, has recently been recognized by the World Health Organization (WHO) as an important emerging disease. It is largely a problem of the poor in remote rural areas and has emerged as an important cause of human suffering. While antimycobacterial therapy is often effective for the earliest nodular or ulcerative lesions, for advanced ulcerated lesi...

Introduction: Necrotizing sialometaplasia is a rare, benign, and self-limiting inflammatory lesion that commonly involves minor salivary glands. It is theoretically associated with ischemia. It is commonly found in the palate, and laryngeal presentation is a very unusual entity. Almost half of such cases have an underlying malignancy; therefore, suspicion of a malignant lesion should be high wh...

Objective: To report a case of severe necrotizing ulcerative periodontitis (NUP) with a rarely associated sequestrum formation in a Nigerian HIV-positive patient. Clinical Presentation and Intervention: A 47-year-old HIV-positive male patient with no history of previous dental visits presented with a severe toothache in his lower jaw of 4 weeks’ duration, which had affected his ability to chew ...

Objective: To report a case of severe necrotizing ulcerative periodontitis (NUP) with a rarely associated sequestrum formation in a Nigerian HIV-positive patient. Clinical Presentation and Intervention: A 47-year-old HIV-positive male patient with no history of previous dental visits presented with a severe toothache in his lower jaw of 4 weeks’ duration, which had affected his ability to chew ...

Objective: To report a case of severe necrotizing ulcerative periodontitis (NUP) with a rarely associated sequestrum formation in a Nigerian HIV-positive patient. Clinical Presentation and Intervention: A 47-year-old HIV-positive male patient with no history of previous dental visits presented with a severe toothache in his lower jaw of 4 weeks’ duration, which had affected his ability to chew ...

BACKGROUND AND AIMS It is believed that adherence of Candida albicans to oral surfaces is a critical event in the coloni-zation and development of oral diseases such as candida-associated denture stomatitis. Although there is considerable infor-mation about the adherence of Candida albicans to buccal epithelial cells and prosthetic materials, there is very little infor-mation available about th...

BACKGROUND AND AIMS Regarding the laser energy delivery with non-tissue alteration when irradiating CO2 laser to the transparent gel, it was worth exploring the clinical efficacy of pain relief on oral ulceration using aphthous stomatitis as a model for painful oral ulcer. The aims of this study were to compare pain scores, daily activity-disturbance scores and sizes of the ulcers between the l...