BACKGROUND AND PURPOSE Intrathecally (i.t.) administered nociceptin/orphanin FQ (N/OFQ) evokes antinociceptive effects in rodents. Recent studies in monkeys demonstrated that i.t. co-application of N/OFQ and morphine elicits synergistic antinociceptive actions suggesting mixed N/OFQ peptide (NOP) and μ opioid receptor agonists as innovative spinal analgesics. Thus, novel N/OFQ related peptides ...

Mobile Ad Hoc Networks (MANETs) consist of mobile nodes which are not controlled by any base station. Mobile nodes act as a major role because of performing the data transmission, route discovery, route maintenance. The packet loss occurs often while the nodes are moving out of range, or the node has not enough either path and link stability or neighbor node stability. In this paper we propose ...

BACKGROUND Nitric oxide is key to endothelial regeneration, but it is still unknown whether endothelial cell (EC) loss results in an increase in NO levels at the wound edge. We have already shown that endothelial damage induces a long-lasting Ca²⁺ entry into surviving cells though connexin hemichannels (CxHcs) uncoupled from their counterparts on ruptured cells. The physiological outcome of inj...

The aim of the present study was to examine the mechanisms responsible for the antinatriuretic effect of the selective, peripherally acting, nociceptin/orphanin FQ peptide (NOP) receptor partial agonist Ac-RYYRWKKKKKKK-NH(2) (ZP120). Using immunohistochemistry, we showed that in the cortex NOP receptors are expressed in the distal convoluted tubules, the connecting tubules, and the collecting d...

The French Ophthalmology Society (SFO) elected as its annual reporter E. Hartmann on "Radiography in ophthalmology. A clinical atlas" (1936), then H. Fischgold et coll. (1966) for "Neuroradiological exploration in ophthalmology" and, for 1996, the author of this article, for "Imaging in ophthalmology," the 3rd phase in this 30 year cycle, due to chance and the need for the development of X-rays...

member of the transmembrane G-protein coupled receptors family comprising d , k and m opioid receptors. Its original homology cloning and the isolation from brain extracts of the endogenous ligand, the heptadecapeptide nociceptin (NC), gave rise to a great interest in clarifying its physiological functions. The receptor, distributed in both central and peripheral nervous systems and in non-neur...

By increasing, the complexity of chips and the need to integrating more components into a chip has made network –on- chip known as an important infrastructure for network communications on the system, and is a good alternative to traditional ways and using the bus. By increasing the density of chips, the possibility of failure in the chip network increases and providing correction and fault tol...

Nociceptin/orphanin FQ (N/OFQ), a peptide closely related to dynorphin A, is the endogenous agonist of the NOP receptor that moderately increases food intake under various conditions. Its orexigenic properties are mediated by the brain circuitry. In the present review, we focus on discussing the nature of hyperphagic effects of N/OFQ with special emphasis on its function within feeding-related ...

A parallel version of a fast algorithm for singular integral transforms [6] is presented. The parallel version only utilizes a linear neighborto-neighbor communication path which makes the algorithm very scalable and suitable for any distributed memory architecture.