background and objectives: to compare pathologic complete response (pcr) in patients with advanced rectal cancer receiving neoadjuvant chemoradiotherapy (nact) by 5-fu or xeloda (capecitabine) with and without eloxatin (oxaloplatin injection). materials and methods: seventy-five consecutive patients with the diagnosis of advanced rectal adenocarcinoma were included. two basic chemotherapy regi...

Background . Gastric cancer is one of the most common cancers with highest incidence and mortality rates worldwide. Gastrectomy/distal subtotal resection D2 lymphadenectomy perioperative chemotherapy FLOT standard treatment for locally advanced gastric cancer. Currently, role chemoradiation therapy in has not been well determined. From 2019 to 2021, a prospective phase 2 clinical trial was unde...

Background To evaluate the economic burden of locally advanced rectal cancer (LARC) treatment from a society perspective through analysis health insurance-derived data commercially insured and Medicare Advantage (MA) patients. Methods Retrospective cost patients undergoing resection within multimodal (neoadjuvant chemoradiation + adjuvant chemotherapy) strategy between January 1, 2010 October 3...

LESSONS LEARNED Colorectal cancers exhibit a high level of cyclooxygenase-2 (COX-2) expression with strong preclinical rationale for improved clinical outcomes with COX-2 inhibition. Celecoxib is a COX-2 inhibitor and we have shown that it can be safely combined with capecitabine and oxaliplatin as part of neoadjuvant treatment with radiation therapy (RT) in rectal cancer.There was a significan...

BackgroundNeoadjuvant chemoradiation is associated with improved survival of superior sulcus cancers, but little data exists regarding clinical T4 lung cancers mediastinal invasion. We hypothesized that neoadjuvant treatment would be in cancer patients invasion.MethodsClinical T4-N0/1-M0 non-small cell from 2006-2015 were identified the National Cancer Database. Patients extension to structures...

Along with their role in the maintenance of nuclear architecture, nuclear lamins also control genomic stability, DNA damage repair, transcription, cell proliferation, differentiation and senescence. Recent reports reveal that prelamin A-processing defects play a role in cancer development by impacting on transcription of key players in the maintenance of the genome stability, including RAD51. H...