Escherichia coli is a major cause of enteric/diarrheal diseases, urinary tract infections, and sepsis. E. coli K1 is the leading gram-negative organism causing neonatal meningitis, but the microbial basis of E. coli K1 meningitis is incompletely understood. Here we employed comparative genomic hybridization to investigate 11 strains of E. coli K1 isolated from the cerebrospinal fluid (CSF) of p...

Staphylococcus aureus strains lacking agr- and sarA-dependent gene products or specific MSCRAMM (microbial surface components recognizing adhesive matrix molecules) adhesins were compared for the ability to activate inflammatory responses in the lung. The mutants were evaluated for virulence in a mouse model of pneumonia and by quantifying their ability to stimulate interleukin-8 (IL-8) and gra...

The aim of this study was to evaluate the incidence of and mortality due to meningitis and compare data according to microbiological diagnosis. This was a ten-year retrospective study conducted at a neonatal intensive care unit (NICU). Newborns with meningitis confirmed by positive CSF culture were included; those with congenital infection or malformations that made lumbar puncture impossible w...

Aim: To investigate the prevalence of meningitis in neonatal sepsis patients at a tertiary care hospital.
 Study Design: A cross-sectional study.
 Place and Duration: Department pediatrics, Civil Hospital Karachi from 11 – 2019 to 04 2020.
 Methodology: total 120 Neonates within first 28 days life with positive blood culture were included this study. Patient’s data was collected ...

ders. A similar polymorphism, believed to be homologous, also exists in nonhuman primates. We have recently analyzed the relationship between the rhesus macaque serotonin transporter (rh5-HTTLPR) genotypes, CSF 5-HIAA concentrations, and aggression. Our results show that rhesus macaques with the short rh5-HTTLPR allele have low CSF 5-HIAA concentrations, and are highly aggressive. However, the ...

Mechanisms leading to breakdown of immunological tolerance and initiation of autoimmunity are poorly understood. Experimental autoimmune gastritis is a paradigm of organ-specific autoimmunity arising from a pathogenic autoimmune response to gastric H/K ATPase. The gastritis is accompanied by autoantibodies to the gastric H/K ATPase. The best characterized model of experimental autoimmune gastri...

The production of colony-stimulating factors (CSF) is delicately controlled through a complex network of humoral and environmental factors. We have studied some of the mechanisms which regulate the production of CSF as compared to general protein synthesis in the lung tissue ill vitro. When lung tissue from mice was cultured for various times in serum free medium, the first detectable le...

Meningitis is an inflammation of the membranes that surround the brain and spinal cord, thereby involving the arachnoid, the pia and the cerebrospinal fluid (CSF). It is divided into viral and bacterial meningitis. For different reasons the diagnosis of bacterial meningitis is very important. The examination of CSF samples may provide information about causative microorganism. The sensivity of ...