PURPOSE To determine the phenotypic and biochemical characteristics of the p.E139K missense variant in tissue inhibitor of metalloproteinase 3 (TIMP3) associated with Sorsby fundus dystrophy (SFD). METHODS The coding regions and adjacent intronic sequence of TIMP3 were amplified by polymerase chain reaction and then analyzed by bidirectional sequencing. Allele-specific PCR was used to determi...

PHOTOGRAPHY WITH INFRA-RED FILM Dekking (1933, 1934) published several photographs of eyes with dense corneal opacities using infra-red film and radiation of a wave-length of about 10,000 A.u. His photographs strikingly demonstrated how infra-red radiation could penetrate a dense corneal opacity, and clearly record the appearance of the iris and pupil, which were invisible by ordinary methods o...

PHOTOGRAPHY WITH INFRA-RED FILM Dekking (1933, 1934) published several photographs of eyes with dense corneal opacities using infra-red film and radiation of a wave-length of about 10,000 A.u. His photographs strikingly demonstrated how infra-red radiation could penetrate a dense corneal opacity, and clearly record the appearance of the iris and pupil, which were invisible by ordinary methods o...

PURPOSE To determine the spectrum of mutations and phenotypic variability within patients with mutations in membrane-type frizzled related protein gene (MFRP). METHODS Individuals were initially ascertained based on a phenotype similar to that previously published in association with MFRP mutations. Affected patients underwent a full ophthalmic examination (best-corrected visual acuity, slit-...

We evaluated the prevalence and risk factors for early age-related macular degeneration (AMD) in Koreans 50 yr of age or older who were examined at a single health promotion center. We retrospectively reviewed the records of 10,449 subjects who visited the center over a 6-month period. Fundus photography was performed on all subjects, and systematic risk factor analysis was conducted using a st...

Assessment of the risk for the development of Age related Macular Degeneration requires reliable detection of retinal abnormalities that are considered as precursors of the disease. Typical symptoms of the later are the so called drusen, which appear as abnormal white-yellow deposits on the retina. Conventional image processing techniques are inappropriate for the segmentation of these features...

PURPOSE To report on a case that developed an atypical form of occult choroidal neovascularization (CNV) after successful macular hole surgery. METHODS Visual acuity change, color fundus photographs, fluorescein and indocyanine green angiograms, and optical coherence tomography results were compared throughout the follow-up duration. PATIENTS A 64-year-old woman with a macular hole in the r...

Age-related macular degeneration (AMD) is a leading cause of vision loss in patients >50 years old. The hallmark of the disease is represented by the accumulation of extracellular material between retinal pigment epithelium and the inner collagenous layer of Bruch's membrane, called drusen. Although identified almost 30 years ago, reticular pseudodrusen (RPD) have been recently recognized as a ...

PURPOSE Enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD OCT) has been recognized as the most sensitive tool to diagnose optic nerve head drusen (ONHD). The relationship between OCT characteristics and visual loss has not been well documented. This study compares EDI SD OCT-determined morphologic characteristics of drusen in eyes with or without visual field (VF) de...