TIn the US, one in 1000 births is affected by neural tube [4] defects (NTD). A neural tube [4] defect is a birth defect involving the malformation of body features associated with the brain and spinal cord. An NTD originates from and is characterized by incomplete closure of the neural tube [4], which is an organizer [5] and precursor of the central nervous system [6]. In humans [7], incomplete...