نتایج جستجو برای: neuromyelitis optic
تعداد نتایج: 46949 فیلتر نتایج به سال:
To the outpatient facility of the Department of Ophthalmology, Faculty Hospital Brno, Czech Republic, E.U., was in June 2013 referred a 24 years old man with the suspicion of Foster Kennedy syndrome. On the fundus examinations, the findings were in correlation with the symptoms of this syndrome: slightly pale optic disc of the right eye and edema with the anterior extension of the optic nerve h...
Sir, We appreciate the thoughtful commentary from Drs Lujan and Horton (2013) based on their patient with Kjer’s dominant optic atrophy with retinal inner nuclear layer microcysts. Their case highlights an emerging understanding that inner nuclear microcysts are not specific to multiple sclerosis. We—and others— have now identified them in neuromyelitis optica (Gelfand et al., 2013; Sotirchos e...
Sir, We appreciate the thoughtful commentary from Drs Lujan and Horton (2013) based on their patient with Kjer’s dominant optic atrophy with retinal inner nuclear layer microcysts. Their case highlights an emerging understanding that inner nuclear microcysts are not specific to multiple sclerosis. We—and others— have now identified them in neuromyelitis optica (Gelfand et al., 2013; Sotirchos e...
OBJECTIVE We examined a cohort of adults with aquaporin-4 (AQP4) antibody-negative neuromyelitis optica/neuromyelitis optica spectrum disorder (NMO/NMOSD) for antibodies to myelin oligodendrocyte glycoprotein (MOG). METHODS We performed a flow cytometry cell-based assay using live human lentivirus-transduced cells expressing full-length surface MOG. Serum was tested in 23 AQP4 antibody-negati...
BACKGROUND Glial fibrillary acidic protein (GFAP) is a specific intermediate filament of the cytoskeleton of the astrocyte and may be used as a specific marker for astrocytic damage. It is detectable in the cerebrospinal fluid following a relapse caused by Multiple Sclerosis (MS) and Neuromyelitis Optica (NMO) spectrum disease. Higher levels are found following an NMO-related relapse. It is not...
BACKGROUND Complement mediated autoimmunity against aquaporin-4 results in astrocytic damage in neuromyelitis optica (NMO). There is evidence for increased CSF glial fibrillary acidic protein (GFAP) and S100B levels in acute NMO. Here we tested whether the CSF finding also holds true for the diagnostic value of serum GFAP and S100B levels in NMO. METHODS A multicentre study included 322 patie...
INTRODUCTION Neuromyelitis optica (NMO) is a severe demyelinating syndrome characterized by optic neuritis (ON) and acute myelitis. The NMO spectrum is actually recognized to typically evolve as a relapsing disorder that also includes patients with atypical unilateral ON and those with index events of ON and myelitis occurring weeks or even years apart (Jarius/Wildemann 2013). NMO was previousl...
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