A. The Existence of Brain Peptides Controlling Adenohypophvsial Functions. Isolation and Characterization of Their Primary Molecular Structures In the early 1950s based on the anatomical observations and physiological experimentation from several groups in the USA and Europe, it became abundantly clear that the endocrine secretions of the anterior lobe of the hypophysis-well known by then to co...

Camillo Golgi and Santiago Ramon y Cajal shared the Nobel Prize in 1906 for their work on the histology of the nerve cell, but both held diametrically opposed views about the Neuron Doctrine which emphasizes the structural, functional and developmental singularity of the nerve cell. Golgi's reticularist views remained entrenched and his work on the nervous system did not venture greatly into ne...

Abstract Background Growth factors execute essential biological functions and affect various physiological pathological processes, including peripheral nerve repair regeneration. Our previous sequencing data showed that the mRNA coding for betacellulin (Btc), an epidermal growth factor protein family member, was up-regulated in rat sciatic segment after injury, implying potential involvement of...

this study was conducted to evaluate the association between aging and regenerative potential of spinal cord injury. three groups of male sprague-dawley rats, including young (40 days), mature (5-6 months) and old (28-29 months) were spinally hemisected at the l1 level. the locomotor performance was assessed weekly for eight weeks after lesion using locomotors' rating scale developed by basso, ...

Abstract Resveratrol, a natural polyphenol found in tempeh, has not been investigated especially vitro as neuroprotective agent against 2-methoxyethanol (2-ME)-induced beta-amyloid cytotoxicity. Beta amyloid peptides (Aβ) could initiate neurotoxic events and neuron-inflammatory response via microglial activation. However, it remains unknown whether the effect of and/or associated with potential...

How proteins/peptides bind to and recognize the inorganic materials with different affinities and specificities has primary importance in biomineralization, hard tissue regeneration (e.g., bone and dental tissues) and making practical materials using synthetic peptides as nucleators, growth modifiers or as control agents [1-4]. The understanding of the possible mechanism(s) of inorganic formati...

Short collagen-like peptides (CLPs) are being proposed as alternatives to full-length collagen for use in tissue engineering, on their own as soft hydrogels, or conjugated to synthetic polymer for mechanical strength. However, despite intended clinical use, little is known about their safety and efficacy, mechanism of action or degree of similarity to the full-length counterparts they mimic. He...

Nanotechnology define the science and engineering providing entirely new tools and capabilities, concerned with the design, synthesis, characterization and application of materials and devices that have a functional organization in at least 1 dimension on the nanometer (one billionth of a meter) capable to interact with cells and tissues at a molecular sub cellular level with a high degree of f...

Bioactive molecules (or signaling molecules) are involved in tissue regeneration and have an important role modulating the microenvironment vivo. chemicals ability to govern host cell motility, proliferation, differentiation, as well enabling cells interact with their surrounding via particular receptors for chemical recognition. This chapter introduces ion-exchange chromatography (IEC) a metho...

Submit Manuscript | http://medcraveonline.com Abbreviations: CAPS-2: Calcium dependent Activator Protein for Secretion 2; BDNF: Brain Derived Neurotrophic Factor; CXCR4: Chemokine Receptor with CXC Motif 4; GABA: Gamma Amino-Butyric Acid; GABA A receptor: Gamma Amino-Butyric Acid Receptor A; GAERS: Genetic Absence Epilepsy Rats from Strasbourg; LGS: Lennox-Gastaut Syndrome; MAP-2: Microtubule A...