Between January 1981 and December 1989, 258 patients with positive syphilis serology underwent lumbar puncture. Nine patients had long-standing neurosyphilis and had lumbar punctures performed during the course of their follow-up. Of the remaining 249 only 12 demonstrated the presence of TPHA in the CSF. The serum TPHA titre for eight of these 12 patients, and seven of the nine (two having no t...

BACKGROUND A concomitant infection with human immunodeficiency virus (HIV) may alter the natural history of other infections. Several reports indicate that syphilis may behave more aggressively when HIV infection is present. CASE A woman presented with a rash involving her hands and feet and progressive loss of the vision in her right eye. Her serologic tests for syphilis and HIV infection we...

New-onset refractory status epilepticus (NORSE) is a syndrome of new-onset drug resistant status epilepticus that often has a catastrophic outcome. A 30-year-old man of Somali origin presented with refractory status to a district general hospital. A clinical diagnosis of NORSE syndrome was made, and he was transferred to the regional epilepsy center for immunomodulatory treatment and considerat...

To our knowledge and literature search, concurrent cryptococcal meningitis and neurosyphilis in a patient have rarely been reported. Here, we report a 37-year-old male with HIV infection presented with headache and dizziness for 5 days along with memory difficulty and personality changes for about 1 week. During the hospital stay, cryptococcal meningitis was confirmed with positive cerebral spi...

As a cause of neuropsychiatric disease, non-HIV related neurosyphilis became uncommon enough for the American Academy of Neurology to drop lumbar puncture from its suggested list of tests for dementia. We reviewed 17 inpatient charts with Centers for Disease Control (CDC) guidelines with definite or probable neurosyphilis. Sixteen presented with neuropsychiatric symptoms, four with overt psycho...

BACKGROUND Syphilis is called the chameleon of the diseases due to its variety of its clinical presentations, potentially affecting every organ of the body. Incidence of this ancient disease is once again on the increase worldwide. CASE PRESENTATION We here report an unusual case of neurosyphilis manifesting with unilateral visual loss and hyponatremia. The patient also had primary syphilitic...