IL-12 is a heterodimeric, pro-inflammatory cytokine that enhances the cytotoxic activity of natural killer (NK) cells and cytotoxic CD8 T-lymphocytes, and induces an IFNa-dominated Th1 CD4 T-lymphocyte response. IL-12 as an immunotherapeutic agent administered subcutaneously in cancer patients has demonstrated clinical responses in melanoma, T cell lymphoma, non-Hodgkin’s lymphoma, and AIDS-rel...

This article reviews the concept of Combination Syndrome and presents a clinical case of a patient with a modern variation to this clinical scenario': The clinical procedures involved in the provision of a maxillary complete denture against a mandibular implant-supported complete fixed prosthesis is described with some suggestions on how to optimise the treatment outcome for the patient.

The recent publication of the American Hypertension Society (ASH) position paper on combination therapy in the treatment of hypertension is essential reading for all physicians and for South African medical aid funders.

JALYN® (DUTASTERIDE/TAMSULOSIN): A NEW OPTION IN BPH n the U.S., the leading method of contraception is the combination oral contraceptive pill. More than 10 million women aged 15-44 years use the birth control pill as their primary method of contraception.1 Since the first BCP approval in 1960, the FDA has approved many oral contraceptive products. Most of these products use ethinyl estradiol ...

The use of new, direct anticoagulants is increasing. Data from both controlled trials and clinical practice have shown that these drugs are as efficacious and safe as warfarin for deep vein thrombosis and pulmonary embolism, and as stroke prophylaxis for patients with atrial fibrillation. But what if platelet inhibition is also indicated? In the following, the combination of antiplatelets and t...

Multi-target tracking system is used to distinguish the class from different targets and obtain the trajectory of all targets from multiple information systems. As a significant and novel information fusion method, evidence theory has been used in multi-target tracking system. The evidence combination rule which is the core of evidence theory is turning into a new research emphasis. Yager combi...

Entropy coding is defined to be the compression of a stream of symbols taken from a known symbol set where the probability of occurrence of any symbol from the set at any given point in the stream is constant and independent of any known occurrences of any other symbols. Shannon and Fano showed that the information of such a sequence could be calculated. When measured in bits the information re...