Maternal thyroid disease can affect the newborn baby leading to neonatal hyperthyroidism or hypothyroidism. Babies born to mothers with thyroid disease get thyroid function tests (TFT) done randomly irrespective of the nature of maternal thyroid disease and medication .The aim of this study was to determine which babies are at-risk and need thyroid function monitoring besides a simple Newborn s...

Breaking the news about an untreatable disease is always difficult. Every professional involved in this activity will be aware of shortcomings in their practice, but it is possible to develop better practices. We report on a protocol developed during the first four years of the evaluation of a newborn screening programme. Although there may be additional constraints in other areas of medical pr...

Capture, coding and communication of newborn screening (NBS) information represent a challenge for public health laboratories, health departments, hospitals, and ambulatory care practices. An increasing number of conditions targeted for screening and the complexity of interpretation contribute to a growing need for integrated information-management strategies. This makes NBS an important test o...

Neonatal congenital hypothyroidism screening is considered to be one of the most effective newborn screening strategies. Neonatal screening for congenital hypothyroidism involves the analysis of thyroid hormone and thyrotropin levels using an immunoassay based technique. Immunoassays are also prone to analytical problems such as assay interference. Immunoassays used for thyroid hormone measurem...

We used ROC plots to evaluate the clinical performance of the Guthrie, Wallac, and Isolab assays for newborn phenylketonuria (PKU) screening and assessed the screening discriminatory power of these three assays by the area under the ROC plot, Youden's J index, and the likelihood ratio. The use of these plots not only allows us to pinpoint the exact cutoff value in screening, but also provides a...

Newborn screening describes various tests that can occur during the first few hours or days of a newborn's life and have the potential for preventing severe health problems, including death. Newborn screening has evolved from a simple blood or urine screening test to a more comprehensive and complex screening system capable of detecting over 50 different conditions. While a number of papers hav...

Newborn bloodspot screening is one of the most enduring and successful population screening initiatives. Yet technological innovation to permit simultaneous measurement of multiple biomarkers - and potentially, entire genomes - has spurred expansion and debate. Through a cross-jurisdictional comparison, we describe the varied roles and reach of screening-related governance structures in the Uni...

Due to high entry barriers, countries might find it daunting implement the NBS program, especially those just trying start it. This review aims discuss Indonesia’s barriers that hinder newborn screening (NBS) implementation while discussing future implications. Literature in Pubmed and Google Scholar was scoured with keywords such as “Newborn Screening”, “Neonatal “Indonesia”, “Asia Pacific”, “...

Address correspondence to: Adrian Davis, Ph.D., Professor, FFPH FSS FRSA, MRC Hearing and Communication Group, University of Manchester, Manchester, M13 9PL, UK, [email protected] Brilliant technology with poor service implementation will not deliver good outcomes, so the task of developing good services to match the new technology needs equal time, skill and commitment. A multicen...

3β-hydroxysteroid dehydrogenase II (3β-HSD) deficiency represents a rare CAH variant. Newborns affected with its classic form have salt wasting in early infancy and genital ambiguity in both sexes. High levels of 17-hydroxypregnenolone (Δ517OHP) are characteristic, but extra-adrenal conversion to 17-hydroxyprogesterone (17OHP) may lead to positive results on newborn screening tests. Filter pape...