Macrophages secrete various cytokines and inflammatory mediators, resulting in playing critical roles inflammation immunity. In this study, we investigated anti-inflammatory immune enhancing properties of PB203, which is a water-soluble extract powder from the fruit Actinidia polygama, macrophages. A. polygama medicinal plant traditionally known to treat abdominal pain, stroke rheumatoid arthri...

Dimethyl sulfoxide (DMSO), an amphipathic molecule composed of one highly polar sulfinyl group and two nonpolar methyl groups, is considered excellent solvent due to its capability dissolve many compounds. Therefore, DMSO widely used solubilize drugs for therapeutic applications. reported possess anti-inflammatory, anticancer, antioxidative capacities, the anti-inflammatory efficacy has been in...

In human monocytes, tumor necrosis factor (TNF) induces a proinflammatory response. In NF-kappaB-inhibited monocytes, TNF stimulates cell death/apoptosis. In the present study, we analyzed the response of acute myeloid leukemia (AML) cells to TNF stimulation in conjunction with NF-kappaB inhibition. In all AML-derived cells tested, NF-kappaB-inhibited cells were resistant to TNF-induced apoptos...

The ATP-binding membrane cassette transporter A1 (ABCA1) plays a protective role in the development of atherosclerosis for the reverse cholesterol transport process. Epigallocatechin-3-gallate (EGCG), which exists abundantly in green tea, exerts an anti-atherosclerotic effect via anti-inflammatory and metabolic regulation activities. Many genes an...

The generation of platelets from megakaryocytes in the steady state is regulated by a variety of cytokines and transcription factors, including thrombopoietin (TPO), GATA-1, and NF-E2. Less is known about platelet production in the setting of stress thrombopoiesis, a pivotal event in the context of cytotoxic chemotherapy. Here we show in mice that the transcription factor Scl is critical for pl...

The generation of platelets from megakaryocytes in the steady state is regulated by a variety of cytokines and transcription factors, including thrombopoietin (TPO), GATA-1, and NF-E2. Less is known about platelet production in the setting of stress thrombopoiesis, a pivotal event in the context of cytotoxic chemotherapy. Here we show in mice that the transcription factor Scl is critical for pl...

A natural carotenoid crocin is contained in saffron and gardenia flowers (crocuses and gardenias) and is used as a food colorant. This study reports the potential inhibitory effects of crocin against inflammation-associated mouse colon carcinogenesis and chemically induced colitis in male ICR mice. In the first experiment, dietary crocin significantly inhibited the development of colonic adenoc...