objectives: dependence and tolerance are major restricting factors in the clinical use of opioid analgesics. in the present study, the effects of thymoquinone, the major constituent of nigella sativa seeds, on morphine dependence and tolerance were investigated in mice. materials and methods: male adult nmri mice were made tolerant and dependent by repeated injections of morphine (50, 50, and 7...

objective: inflammation and oxidative stress is considered to have a crucial role in induction of nephropathy. curcuma longa (c. longa) and nigella sativa (n. sativa) have anti-inflammatory and antioxidant effects. this study was designed to investigate the effect of mixed hydro-alcoholic extract of n.sativa and c. longa on the oxidative stress induced by adriamycin (adr) in rat kidney. materia...

Nigella sativa L. (family Ranunculaceae) is an annual herb of immense medicinal properties because of its major active components (i.e., thymoquinone (TQ), thymohydroquinone (THQ), and thymol (THY)). Plant tissue culture techniques like elicitation, Agrobacterium mediated transformation, hairy root culture, and so on, are applied for substantial metabolite production. This study enumerates the ...

Among the promising medicinal plants, Nigella sativa, also known as Black seeds and Black cumin, has been called the “Blessed Seed” for its miraculous curing ability. Present study has been carried out to evaluate anti-oxidant properties at different germination stages of seeds of Nigella sativa. The level of antioxidant enzymes, SOD and CAT decreased gradually in the samples from first day to ...

Nigella sativa (NS) (Ranunculaceae family) is generally utilized as a therapeutic plant all over the world. The seeds of the plant have a long history of use in different frameworks of medicines and food. In Islamic literature, it is considered as one of the greatest forms of therapeutics. It has been widely used to treat nervous system diseases such as memory impairment, epilepsy, neurotoxicit...