The present study was performed to determine the effects of cyclooxygenase (COX)-1 and COX-2 inhibition on blood pressure and renal hemodynamics in transgenic rats with inducible malignant hypertension [strain name: TGR(Cyp1a1Ren2)]. Male Cyp1a1-Ren2 rats (n = 7) were fed a normal diet containing the aryl hydrocarbon, indole-3-carbinol (I3C; 0.3%), for 6-9 days to induce malignant hypertension....

Probable Hypoglycaemia Induced by Single Dose Nimesulide Sir, A 44 years non-alcoholic non-smoker healthy Hindu male from rural region was admitted with history of body ache and headache from 2-3 hours after a full vegetarian meal for which he took 2 tabs of Nimesulide (100mg each) and slept. Patient was found unconscious by the attendant after 6-8 hrs approximately and was not arousable. He wa...