Oral anticoagulants act by competitive inhibition of vitamin K, which is essential for the production of Certain clotting factors : notably Factors VII, IX, and X, and Prothrombin. Vitamin K is therefore the physio'ogical antagonist of oral anticoagulants, and when Qiven in pharmacological doses eventually reverses 'heir effect. However, variations of vitamin K in the diet (it is found in dark ...

Buprenorphine is available in Singapore as substitution treatment for opioid dependence since 2002. This study surveys buprenorphine related deaths in Singapore between September 2003 and December 2004. The aims are to establish the autopsy prevalence of buprenorphine related deaths and the demographical and toxicological profile of the cases. Toxicological screening was performed for all unnat...

OBJECTIVE Infantile spasms (IS) are among the most catastrophic epileptic syndromes of infancy. The purpose of this study was to compare efficacy and safety of topiramate (TPM) and nitrazepam (NZP) as first-line drugs in the treatment of IS. MATERIALS & METHODS In a parallel single-blinded randomized clinical trial, 50 patients with IS referred to Pediatric Neurology Clinic of Shahid Sadoughi...