BACKGROUND Fractional exhaled nitric oxide is elevated in allergen-provoked asthma. The cellular and molecular source of the elevated fractional exhaled nitric oxide is, however, uncertain. OBJECTIVE To investigate whether fractional exhaled nitric oxide is associated with increased airway epithelial inducible nitric oxide synthase (iNOS) in allergen-provoked asthma. METHODS Fractional exha...

The behavioral-state related firing of mesopontine cholinergic neurons of the laterodorsal tegmental nucleus appears pivotal for generating both arousal and rapid-eye-movement sleep. Since these neurons express high levels of nitric oxide synthase, we investigated whether their firing increases local extracellular nitric oxide levels. We measured nitric oxide in the laterodorsal tegmental nucle...

Duchenne Muscular Dystrophy is a rare and fatal neuromuscular disease in which the absence of dystrophin from the muscle membrane induces a secondary loss of neuronal nitric oxide synthase and the muscles capacity for endogenous nitric oxide synthesis. Since nitric oxide is a potent regulator of skeletal muscle metabolism, mass, function and regeneration, the loss of nitric oxide bioavailabilit...

Nitric oxide has been shown to have important physiological regulatory roles, i. e, vasodilation, neurotransmitter release, etc. Now, we review its role as an antibacterial and antiviral agent. Nitric oxide has also been identified as an important factor in the development of non-specific immunity. And accordingly, nitric oxide synthase (NOS), the catalytic enzyme producing nitric oxide, is a k...

Objective(s):Some pathologic situations such as diabetes and metabolic syndrome are associated with alternation in nitric oxide level. Incidence of these condition increases with aging. On the other hand, insulin secretion is modulated by nitric oxide, and nitric oxide synthase (NOS) activity is also altered in diabetes. In this study, modification in the enzyme activity associated with aging a...

Stress and chronic pain have been shown to prevent the development of tolerance to morphine analgesia, which appears to be related to neuroendocrine activity and alternation in neurochemicals. Also the involvement of nitric oxide (NO) has been implicated in tolerance to morphine analgesia. In our pervious study, we showed that co-administration of swim stress (ss) with chronic morphine, prevent...

the aim of the study was to evaluate the clinical usefulness of n-terminal pro-brain natriuretic peptide (nt-pro bnp) and nitric oxide (no) with echocardiography (gold standard test) in diagnosis of canine cardiomyopathy. out of 374 cases, 82 cases showing cardiovascular abnormalities including 16 cases of cardiomyopathy were further selected for standardization of biomarkers. significant (p

the no removal over oxide sorbents (k2o/al2o3 , cao/al2o3 and bao/al2o3) at a loading of up to 25 wt.% was investigated using a synthetic diesel exhaust gas containing  1,000 ppm no, 1000 ppm iso-butane (i-c4h10), 8% o2 and n2 balance. the reactor was operated  at 250 oc to 450 oc for the activity study. no was effectively stored (removal efficiencies between 30-60 %) as nitrate under experimen...

the effect of chronic inflammation induced by complete freund's adjuvant (cfa) on anterior blood vessels of knee joint and its diameter was studied. blood flow changes in response to phenylephrine (αl-adrenoceptor agonist) in cfa-treated and contralateral knee joints were observed over a 40-day period, using laser doppler flowmetery (ldf) technique. unilateral injection of cfa (0.2 ml) inc...

introduction: the aim of the present study was to determine direct effects of no modulation on protective electrophysiological properties of atrioventricular node (av node) in the experimental model of af in rabbit. methods: isolated perfused rabbit av nodal preparations were used in two groups. in the first group (n=7), lname (50μm) was applied. in the second group (n=12), different concentrat...