The thermal treatment of [Ru2(CO)6(μ-η,η-C4H3O){μ-P(C4H3O)2}] 1 with dimethyl acetylenedicarboxylate (DMAD) at 110 oC leads to cyclotrimerization of DMAD. The cyclotrimerization product hexamethyl benzenehexacarboxylate, [C6(COOCH3)6] 2, was obtained in 37% yield and characterized by a combination of spectroscopic data and single crystal X-ray diffraction study. Compound 2 crystallizes in the m...

The reaction of [Ru(C(9)H(10)BN(6))Cl(C(18)H(15)P)(2)] with benzo-nitrile leads to crystals of the title compound, [Ru(C(9)H(10)BN(6))Cl(C(18)H(15)P)(C(7)H(5)N)]·C(2)H(5)OH. In the crystal structure, the environment about the ruthenium metal center corresponds to a slightly distorted octa-hedron with an average N-Ru-N bite angle of the Tp ligand of 86.6 (2)°.

Bioorthogonal click reactions are powerful tools to specifically label biomolecules in living cells. Considerable progress has been made in site-specific labeling of proteins and glycans in complex biological systems, but equivalent methods for mRNAs are rare. We present a chemo-enzymatic approach to label the 5' cap of eukaryotic mRNAs using a bioorthogonal photoclick reaction. Herein, the N7-...

In the title compound, C8H3N3O2 (systematic name: 4-nitro-benzene-1,2-dicarbo-nitrile), the nitro group is twisted out of the plane of the benzene ring to which it is attached [O-N-Cring-Cring torsion angle = 9.80 (13)°]. In the crystal packing, supra-molecular layers with a zigzag topology in the ac plane are sustained by C-H⋯N inter-actions.

The reductive amination of benzoic acid and its derivatives would be an effective addition to current synthesis methods for benzylamine. However, with technology it is very difficult keep the aromaticity intact when starting from acid, salt wastes are often generated in process. Here, we report a heterogeneous catalytic system such amination, requiring solely H2 NH3 as reactants. Ag/TiO2 or Au/...

Solid-phase oligonucleotide conjugation by nitrile oxide-alkyne click cycloaddition chemistry has been successfully demonstrated; the reaction, compatible with all nucleobases, requires no metal catalyst and proceeds under physiological conditions.

Due to the importance and various applications of nitriles especially in medicinal productions, a new method for conversion of aldehydes to nitriles has been presented. Several nitrile-containing aromatic compounds were synthesized through the treatment of various aldehydes and hydroxylamine hydrochloride as nucleophile in the presence of ferric hydrogen sulfate as a heterogeneous, efficient, a...

We report a new, simple and air-stable iron(II) complex pre-catalyst for the synthesis of substituted pyridines via a [2+2+2] cycloaddition between diynes and nitrile derivatives.

Amidation of nitrile with N,N-dimethylformamide (DMF) was catalyzed by Cu2O with 1,10-phenanthroline as a ligand under an oxygen atmosphere. A variety of N,N-dimethyl benzamides were obtained in yields up to 84%.

A series of 'dual-functionalised' ionic liquids, comprising imidazolium cations with various functionalities and the nitrile functionalised anion [CH3CH(BF3)CH2CN]- have been prepared; some exhibit very low viscosities-a highly valuable property in many applications.