The petroleum ether, chloroform, methanol and aqueous extracts of the leaves of Ageratum conyzoides Linn. (Asteraceae) were evaluated for their wound healing activity in rats using excision (normal and infected), incision and dead space wound models respectively. The effects of test samples on the rate of wound healing were assessed by the rate of wound closure, period of epithelialisation, wou...

Escherichia coli SOS functions constitute a multifaceted response to DNA damage. We undertook to study the role of yafP, a SOS gene with unknown function. yafP is part of an operon also containing the dinB gene coding for DNA Polymerase IV (PolIV). Our phylogenetic analysis showed that the gene content of this operon is variable but that the dinB and the yafP genes are conserved in the majority...

The reductive products of several nitroaromatic compounds have been found to be toxic, mutagenic, and carcinogenic. The nitroreductases present in intestinal microflora have been implicated in the biotransformation of these compounds to their deleterious metabolites. A “classical” nitroreductase has been purified from Enterobacter cloacae 587-fold using a protocol which yields approximately 1 ...

The evaluation of wound healing activity was conducted to study the effect of various extracts of Carmona retusa (Vahl) Masam. The ointment was prepared from the alcohol extract of root, stem and leaves with petroleum jelly as a base in 5% and 10% concentrations. Swiss albino mice were used for the evaluation of wound healing activity. The ointment prepared from various parts exhibited consider...

Furacin urethral suppositoriest (containing nitrofurazone 0 2 per cent. and 2 per cent. diperodon hydrochloride (N.N.R.) a local anaesthetic, dissolved in a water-dispersible base composed of glyceryl monolaurate and sorethytan (4) monostearate (Tween 61) are available for the treatment of non-gonorrhoeal, bacterial (granular) urethritis of women, a condition not generally recognized in Great B...

The flowers of Malva sylvestris Linn. (Malvaceae) and Punica granatum Linn. (Punicaceae) are important medicinal plants in Iranian traditional medicine (Unani) whose have been used as remedy against edema, bum, wound and for their carminative, antimicrobial and anti-inflammatory activities. The diethyl ether extract of M. sylvestris and P. granatum flowers were used to evaluate the wound healin...

To investigate the antimicrobial, antioxidant and wound healing activities of different fractions of the methanolic extracts of the leaves of Ipomoea Carnea was investigated, Antimicrobial activities was carried out by disc diffusion method and MBC, the wound healing activity was carried out using ether anaesthetized rats in two different wound models i.e. Incision and Excision at two different...

The effect of cysteamine and glutathione addition on the redox behaviour of metronidazole, chloramphenicol, M&B 4998, nitrofurazone, and nifuroxime has been studied by electrochemical techniques. The presence of thiol influences the redox behaviour of the nitro compound in a number of ways. In aqueous media, the single-step nitro/hydroxylamine reduction shows a decrease in current and a shift t...

The reductive products of several nitroaromatic compounds have been found to be toxic, mutagenic, and carcinogenic. The nitroreductases present in intestinal microflora have been implicated in the biotransformation of these compounds to their deleterious metabolites. A "classical" nitroreductase has been purified from Enterobacter cloacae 587-fold using a protocol which yields approximately 1 m...

We identified the nfsA gene, encoding the major oxygen-insensitive nitroreductase in Escherichia coli, and determined its position on the E. coli map to be 19 min. We also purified its gene product, NfsA, to homogeneity. It was suggested that NfsA is a nonglobular protein with a molecular weight of 26,799 and is associated tightly with a flavin mononucleotide. Its amino acid sequence is highly ...