Diabetes mellitus is one of the most common chronic diseases worldwide. Diabetic cardiomyopathy (DM) is the deterioration of the myocardial function and morphology produced by the altered glucose metabolism imposed in diabetes. This process of cardiac deterioration involves the generation of oxidative species. In the diabetic heart, several sources contribute to the observed oxidative stress, s...

N-nitroso compounds are potent carcinogens detected in foodstuffs. The importance of dietary nitrosamines in relation to human cancer development is, however, uncertain. We studied the relationship between intake of nitrates, nitrites and N-nitrosodimethylamine (NDMA) and risk of cancers of the gastro-intestinal tract in a cohort of 9,985 adult Finnish men and women. During a follow-up period o...

Titanium and titanium alloy materials are commonly used in joint replacements, due to the high strength of the materials. Pathogenic microorganisms can easily adhere to the surface of the metal implant, leading to an increased potential for implant failure. The surface of a titanium-aluminum-vanadium (Ti-6Al-4V) metal oxide implant material was functionalized to deliver an small antibacterial m...

To explore the potential role of some bacterial metabolites of chloramphenicol (CAP) in CAP-induced hematotoxicity, we examined their cytotoxic effects on bone marrow cells in vitro using a number of cytotoxicity parameters. Among the metabolites tested, dehydro-CAP (DHCAP) and p-nitrophenyl-2-amino-3 hydroxypropanone-HCI (NPAP) were more toxic than CAP. DHCAP was at least as toxic as nitroso-C...

Red and processed meat consumption is associated with the risk of colorectal cancer. Three hypotheses are proposed to explain this association, via heme-induced oxidation of fat, heterocyclic amines, or N-nitroso compounds. Rats have often been used to study these hypotheses, but the lack of enterosalivary cycle of nitrate in rats casts doubt on the relevance of this animal model to predict nit...

Endothelial NO production results in local formation of adducts that may act as storage forms of NO. Because little is known about their chemical nature, concentrations, and possible role in vascular biology, we sought to characterize those species basally present in rat aorta, using two independent approaches. In the first approach, tissue homogenates were analyzed by using chemiluminescence- ...

K-ra.v oncogene mutation has been shown to be a frequent event in pancreatic ductal adenocarcinomas induced by the carcinogen V-nitroso-bis(2-oxopropyl)amine in the hamster. The present study exam ines the mutational status of the K-r«.v oncogene in lesions that precede the appearance of invasive ductal adenocarcinomas. Syrian golden ham sters (80-100 g) received 12 weekly doses of 15 mg/kg A'...

Complexes derived from some 1-Phenyl-3-methyl-4-nitroso-5-pyrazolone (L1), 1,3-diphenyl-4nitroso-5-pyrazolone (L2) and 1-phenyl-3-anilino4-nitroso-5-pyrazolone (L3) with Mn, Co, Ni, Cu and Zn metal ions have been prepared. Structural investigation of the ligands and their complexes has been made based on elemental analysis, infrared (FT-IR), ultraviolet and visible spectra (UV-Vis.), proton nuc...