The architectural transcription factor SRY (sex-determining region of the Y chromosome) plays a key role in sex determination as indicated by the fact that mutations in SRY are responsible for XY gonadal dysgenesis in humans. Although many SRY mutations reduce DNA-binding/bending activity, it is not clear how SRY mutations that do not affect interaction with DNA contribute to disease. The SRY h...

Eighteen patients with idiopathic hypersomnia (IH) were compared with 50 patients with the narcoleptic syndrome of cataplexy and daytime sleepiness (NLS) using self report questionnaires and a diary of sleep/wake patterns. The IH group reported more consolidated nocturnal sleep, a lower propensity to nap, greater refreshment after naps, and a greater improvement in excessive daytime sleepiness ...

The nonlinear Schrödinger-Helmholtz (SH) equation in N space dimensions with 2σ nonlinear power was proposed as a regularization of the classical nonlinear Schrödinger (NLS) equation. It was shown that the SH equation has a larger regime (1 ≤ σ < 4 N ) of global existence and uniqueness of solutions compared to that of the classical NLS (0 < σ < 2 N ). In the limiting case where the Schrödinger...

There are presented results of the complex NLS-research of patients with space-occupying lesions of orbital and extra-orbital genesis which were confirmed by the results of the clinical research, MRT and CT scanning and also morphologically verified in patients who had underwent surgery. It is determined that spectral-entropic analysis of tissues structure of spectral parameters of blood circul...

Nevus lipomatosus superficialis (NLS) is an uncommon hamartomatous lesion of the skin characterized by the presence of clusters of mature fat cells among the collagen bundles of the dermis. Usually, the number of adnexal structures is reduced in NLS as compared to the normal adjacent skin, but their morphology is not altered. Nevertheless, in some instances, associated pilar abnormalities have ...

Axoplasmic proteins containing nuclear localization signals (NLS) signal retrogradely by an unknown mechanism in injured nerve. Here we demonstrate that the importin/karyopherin alpha and beta families underlie this process. We show that importins are found in axons at significant distances from the cell body and that importin beta protein is increased after nerve lesion by local translation of...

INTRODUCTIONThe MS2 system provides optimal sensitivity for single-molecule detection in cells. It requires two genetically encoded moieties: a reporter mRNA that contains MS2 binding site (MBS) stem loops and a fluorescent MS2 coat protein (MCP-xFP) that binds to the stem loops with high affinity, thus tagging the mRNA within the cell. This protocol describes transfection of COS-7 cells with r...

We study the nonlinear-damping continuation of singular solutions of the critical and supercritical NLS. Our simulations suggest that for generic initial conditions that lead to collapse in the undamped NLS, the solution of the weakly-damped NLS iψt(t, x) + ∆ψ + |ψ |p−1ψ + iδ|ψ |q−1ψ = 0, 0 < δ ≪ 1, is highly asymmetric with respect to the singularity time, and the post-collapse defocusing velo...

In this paper, we review several recent results concerning well-posedness of the one-dimensional, cubic Nonlinear Schrödinger equation (NLS) on the real line R and on the circle T for solutions below the L-threshold. We point out common results for NLS on R and the so-called Wick ordered NLS (WNLS) on T, suggesting that WNLS may be an appropriate model for the study of solutions below L(T). In ...

The adiabatic N-soliton train interactions for the scalar nonlinear Schrö-dinger (NLS) equation and its perturbed versions are well studied. Here we briefly outline how they can be generalized for the higher NLS-type equations and for the multicompo-nent NLS equations. It is shown that in all these cases the complex Toda chain plays fundamental role. 1. Introduction. In a number of applications...