نتایج جستجو برای: nmda receptors

تعداد نتایج: 230249  

Journal: :The Journal of Neuroscience 2016

Introduction: Ecstasy is an amphetamine derivative, which its use has been consistently increasing over the past years. Ecstasy interacts with the glutamatergic system and it is known that glutamate receptors have a key role in learning and memory. The aim of this study was to investigate the interaction of ecstasy and glutamatergic system on learning and memory. Methods: Fifty-six male Wis...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Sharon A Swanger Katie M Vance Jean-François Pare Florence Sotty Karina Fog Yoland Smith Stephen F Traynelis

The GluN2D subunit of the NMDA receptor is prominently expressed in the basal ganglia and associated brainstem nuclei, including the subthalamic nucleus (STN), globus pallidus, striatum, and substantia nigra. However, little is known about how GluN2D-containing NMDA receptors contribute to synaptic activity in these regions. Using Western blotting of STN tissue punches, we demonstrated that Glu...

Journal: :Journal of neurophysiology 2001
E W Keefer A Gramowski G W Gross

Cultured spinal cord networks grown on microelectrode arrays display complex patterns of spontaneous burst and spike activity. During disinhibition with bicuculline and strychnine, synchronized burst patterns routinely emerge. However, the variability of both intra- and interculture burst periods and durations are typically large under these conditions. As a further step in simplification of sy...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
Ruifa Mi Xiaopei Tang Ralph Sutter Desheng Xu Paul Worley Richard J O'Brien

We have explored the ability of axons from spinal and hippocampal neurons to aggregate NMDA- and AMPA-type glutamate receptors on each other as a way of exploring the molecular differences between their presynaptic elements. Spinal axons, which normally cluster only AMPA-type glutamate receptors on other spinal neurons, cluster both AMPA- and NMDA-type glutamate receptors on the dendritic shaft...

Journal: :The Journal of Physiology 2008
Huaxia Tong Alasdair J Gibb

NMDA receptors are of particular importance in the control of synaptic strength and integration of synaptic activity. Dopamine receptor modulation of NMDA receptors in neonatal striatum may influence the efficacy of synaptic transmission in the cortico-striatal pathway and if so, this modulation will affect the behaviour of the basal ganglia network. Here, we show that in acute brain slices of ...

Journal: :The European journal of neuroscience 1996
P rossi E D'Angelo V Taglietti

UNLABELLED Whole-cell patch-clamp recordings in rat cerebellar slices were used to investigate the effect of metabotropic glutamate receptor activation on mossy fibre-granule cell synaptic transmission. Transient application of 20 microM 1S, 3R-aminocyclopentane-1, 3-dicarboxylic acid simultaneously with low-frequency NMDA receptor activation induced long-lasting non-decremental potentiation of...

Journal: :Neurotoxicology 2013
Yu-Jiao Li Qi Yang Kun Zhang Yan-Yan Guo Xu-Bo Li Le Yang Ming-Gao Zhao Yu-Mei Wu

Cytisine (CYT), one of the principal bioactive components derived from the seeds of Cytisus laborinum L, has been widely used for central nervous system (CNS) diseases treatment. The present study investigated the protective effect of CYT on cultured cortical neural injury induced by N-methyl-d-aspartate (NMDA). Our data showed that CYT conferred protective effect against loss of cellular viabi...

Elaheh Noshinfar, Maspumeh Sabet-kasaei,

Introduction: Many people with amnesia would like to try herbal therapies. Ginkgo biloba is one of the most popular herbs which is used to treat amnesia. The beneficial effects of this plant, however, has not been scientifically assessed yet. Although, there have been some reports on the memory enhancement effect of Ginkgo biloba, the mechanism of its action is not yet explained well. Consi...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Deniz Atasoy Mert Ertunc Krista L Moulder Justin Blackwell ChiHye Chung Jianzhong Su Ege T Kavalali

In a synapse, spontaneous and action-potential-driven neurotransmitter release is assumed to activate the same set of postsynaptic receptors. Here, we tested this assumption using (+)-5-methyl-10,11-dihydro-5H-dibenzo [a,d] cyclohepten-5,10-imine maleate (MK-801), a well characterized use-dependent blocker of NMDA receptors. NMDA-receptor-mediated spontaneous miniature EPSCs (NMDA-mEPSCs) were ...

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