BACKGROUND Oral malignant melanoma (OMM) is an aggressive tumor with very low survival rate and easy to metastasize. Pleural metastatic melanoma via primary OMM is rare. CASE PRESENTATION In this report, we presented a case of metastatic malignant melanoma of the pleura originated from OMM. A 54-year-old man without primary skin lesion was diagnosed multiple nodular shadows, pleural invasion,...

T here is, perhaps, no other class of neoplasm in the discipline of cutaneous medicine that evokes fear in patients as deeply as does melanoma. This sarcoma, seemingly unpredictable as it is in its clinical presentation and its histologic mimicry of melanocytic nevi and other lineages of neoplasms, is indeed worthy of our respectebut not our fear. Fear is overcome by knowledge, and methods of d...

INTRODUCTION Malignant melanoma is the most aggressive skin cancer and its incidence has been increasing in recent decades. The cure depends on early diagnosis and understanding melanoma epidemiology is of great importance for the implementation of programs of primary prevention and early detection. MATERIAL AND METHODS We reviewed the clinical cases of primary cutaneous malignant melanoma di...

PURPOSE The purpose of the present work was to analyze the expression of beta-catenin in a panel of superficial and nodular spreading primary and metastatic melanomas, and to correlate the level of immunohistochemical staining to clinicopathological parameters. EXPERIMENTAL DESIGN Expression of beta-catenin was examined by immunohistochemistry in 106 superficial and 58 nodular spreading prima...

According to data from the literature and to new data from the German central registry for malignant melanomas from the German Society of Dermatology, a summary is given about the occurrence of malignant melanoma in children and adolescents up to 18 years of age. During the first 10 years of life the occurrence of a melanoma is extremely rare, but slowly increases after the first decade. Severa...

Lymphatic invasion and accumulation of continuous collagen bundles around tumor cells are associated with poor melanoma prognosis, but the underlying mechanisms and molecular determinants have remained unclear. We show here that a copy-number gain or overexpression of the membrane-type matrix metalloproteinase MMP16 (MT3-MMP) is associated with poor clinical outcome, collagen bundle assembly ar...

Introduction. Primary malignant melanoma of the urethra is a rare tumour (0.2% of all melanomas) that most commonly affects the meatus and distal urethra and is three times more common in women than men. Case. A 76-year-old lady presented with vaginal pain and discharge. On examination, a 4 cm mass was noted in the vagina and biopsy confirmed melanoma of a balloon type. Preoperative CT showed n...

Topical photodynamic therapy (PDT) is a widely used non-invasive treatment for certain non-melanoma skin cancers, permitting treatment of large and multiple lesions with excellent cosmesis. High efficacy is demonstrated for PDT using standardized protocols in non-hyperkeratotic actinic keratoses, Bowen's disease, superficial basal cell carcinomas (BCC) and in certain thin nodular BCC, with supe...

CS: Cowden syndrome PTEN: phosphatase and tensin homolog INTRODUCTION Iris mammillation is an uncommon congenital anomaly of the eye that is rarely reported in the literature; initial reports describe iris mammillations using different terminology, such as bilateral iris melanosis, dotted Swiss iris, and bilateral diffuse iris nodular nevi. Microscopic examination finds focal nesting of spindle...