Induction of apoptotic cell death in response to chemotherapy and other external stimuli has proved extremely difficult in melanoma, leading to tumor progression, metastasis formation and resistance to therapy. A promising approach for cancer chemotherapy is the inhibition of proteasomal activity, as the half-life of the majority of cellular proteins is under proteasomal control and inhibitors ...

We show how to construct efficient, unconditionally secure non-malleable codes for bounded output locality. In particular, our scheme is resilient against functions such that any output bit is dependent on at most n bits, where n is the total number of bits in a codeword and 0 ≤ δ < 1 a constant. Notably, this tampering class includes NC .

BACKGROUND Congenital adrenal hyperplasia (CAH) due 21-hydroxylase deficiency (21-OHD) is a common autosomal recessive disorder. It is caused by defects in the CYP21A2 gene. OBJECTIVE Our aim was to determine the frequency of common gene mutations and to evaluate genotype-phenotype correlations in Turkish 21-OHD patients. METHODS Molecular analysis of the CYP21A2 gene was performed for the ...

Han, Jaemin Ph.D., Purdue University, December 2013. Multi-session Network Coding Characterization using New Linear Coding Frameworks. Major Professor: ChihChun Wang Professor. Recently, Network Coding (NC) has emerged as a promising technique in modern communication networks and has shown extensive potentials in practical implementations and theoretical developments. Nevertheless, the NC probl...

BACKGROUND: Ovine pulmonary adenocarcinoma (OPA) is a worldwide contagious bronchioalveolar carcinoma caused by infection of a beta retrovirus in sheep and less in goat. Neoplastic proliferation of type II pneumocytes and clara cells, produce papillary to acinar tumoral pattern with infiltration of macrophages, lymphocytes and plasma cells and interstitial fibrosis tissue. OBJECTIVES: This stud...

The aim of the study is to evaluate the contrast enhanced power doppler technique as a method to detect and differentiate vascular patterns of focal liver lesions. Fourty-nine patients with focal liver lesions were included in the study, twenty-nine of them with malignant liver lesions (9 HCC, 20 metastatic), twenty patients with benign lesions (12 haemangiomas, 5 focal nodular hyperplasia, 3 f...

Hepatocellular lesions can be neoplastic or non-neoplastic. The common non-neoplasms include regenerative hyperplasia, focal accumulation of fat, focal nodular hyperplasia (FNH), macroregenerative nodules (MRN), and nodular regenerative hyperplasia (NRH). The neoplasms include hepatic adenomas, hepatocellular carcinomas (HCC) and their variants. Accurate diagnosis of these lesions can be someti...

In the context of inter-jet energy flow, we present the first quantitative result of the resummation of non-global logarithms at finiteNc. This is achieved by refining Weigert’s approach in which the problem is reduced to the simulation of associated Langevin dynamics in the space of Wilson lines. We find that, in e+e− annihilation, the exact result is rather close to the result previously obta...