Background. A convenient, private, and accessible HIV self-testing strategy stands to complement facility-based conventional testing. Over-the-counter oral HIV self-tests are approved and available in the United States, but not yet in Canada. Canadian data on self-testing is nonexistent. We investigated the feasibility of offering an unsupervised self-testing strategy to Canadian students. Meth...

One of the biggest challenges in modern pharmaceutical drug discovery is the effective management and exploitation of research data. How can one find those relatively small nuggets of knowledge buried in the great morass of data being generated by High Throughput Screening systems? One potential answer is by using Enterprise MinerTM software! This talk will describe how it can be used to find s...

Self-medication with antibiotics is a major concern worldwide and a real problem with public health importance [1]. Most of the recent studies have revealed high prevalence of self-medication in some countries and reported positive correlation of excessive drug use with antimicrobial resistance [2-6]. When antibiotics are used without medical prescription, the increased risk of resistance is as...

Structural MS is a rapidly growing field with many applications in basic research and pharmaceutical drug development. In this feature article the overall technology is described and several examples of how hydroxyl radical based footprinting MS can be used to map interfaces, evaluate protein structure, and identify ligand dependent conformational changes in proteins are described.

This postcoital sperm assessment study was performed over a 10 month time period (November 2014-August 2015). Fifteen couples enrolled in the study. The study was a non-blinded, non-randomized, single-center comparison study comparing The Stork® OTC (Rinovum Women's Health, Monroeville, PA) to natural intercourse (NI), using the subjects as their own control/baseline. This was an efficacy study...

If you get a hangnail, it?s recommended that you avoid pulling or biting it off. Instead, remove the excess skin with nail clippers or nail scissors. To avoid infection, make sure to wash your hands regularly. You mentioned that your hangnail is very sore and swollen ? this could be a sign of infection. It?s wise to apply some over-the-counter antibacterial ointment or cream (after you clean an...

OBJECTIVE The purpose of this systematic review was to evaluate the effectiveness of roll-over protection structures (ROPS) as an engineering control for prevention of fatalities from farm tractor roll-overs. METHODS Using a systematic approach to literature searching, relevant studies from peer-reviewed journals, technical and government reports, and unpublished reports were retrieved. Studi...

The lifetime of the B+ c meson is measured using semileptonic decays having a J/ψ meson and a muon in the final state. The data, corresponding to an integrated luminosity of 2 fb−1, are collected by the LHCb detector in pp collisions at a centre-of-mass energy of 8 TeV. The measured lifetime is τ = 509± 8± 12 fs, where the first uncertainty is statistical and the second is systematic.

To understand whether and how pre-trade transparency would affect over-the-counter markets, we construct a search model and test our model implications in corporate bond markets. Based on our search model, we argue that the increase in pre-trade information, which refines traders’ information sets, enhances traders’ bargaining positions relative to dealers’. Thus, traders’ transaction costs mea...

BACKGROUND Self-tests can be used by members of the public to diagnose conditions without involving a doctor, nurse or other health professional. As technologies to design and manufacture diagnostic tests have developed, a range of self-tests have become available to the public to buy over-the-counter and via the Internet. This study aims to describe how many people have used self-tests and ide...