We describe a computational approach to the embedding problem in structural molecular biology. The approach is based on a dissimilarity parameterization of the problem that leads to a large-scale nonconvex bound constrained matrix optimization problem. The underlying idea is that an increased number of independent variables decouples the complicated effects of varying the location of individual...

The self-scaling quasi-Newton method solves an unconstrained optimization problem by scaling the Hessian approximation matrix before it is updated at each iteration to avoid the possible large eigenvalues in the Hessian approximation matrices of the objective function. It has been proved in the literature that this method has the global and superlinear convergence when the objective function is...

Consensus optimization has received considerable attention in recent years. A number of decentralized algorithms have been proposed for convex consensus optimization. However, on consensus optimization with nonconvex objective functions, our understanding to the behavior of these algorithms is limited. When we lose convexity, we cannot hope for obtaining globally optimal solutions (though we st...

Abstract: We consider a semi-infinite optimization problem in Banach spaces, where both the objective functional and the constraint operator are compositions of convex nonsmooth mappings and differentiable mappings. We derive necessary optimality conditions for these problems. Finally, we apply these results to nonconvex stochastic optimization problems with stochastic dominance constraints, ge...

Lagrangian bounds, i.e. bounds computed by Lagrangian relaxation, have been used successfully in branch and bound bound methods for solving certain classes of nonconvex optimization problems by reducing the duality gap. We discuss this method for the class of partly linear and partly convex optimization problems and, incidentally, point out incorrect results in the recent literature on this sub...

The concave utility in the Network Utility Maximization (NUM) problem is only suitable for elastic flows. However, the networks with the multiclass traffic, the utility of inelastic traffic is usually represented by the sigmoidal function which is a nonconcave function. Hence, the basic NUM problem becomes a nonconvex optimization problem. Solving the nonconvex NUM distributively is a difficult...

Here, a quasi-Newton algorithm for constrained multiobjective optimization is proposed. Under suitable assumptions, global convergence of the algorithm is established.