Basidiomycete mushrooms represent a valuable source of biologically active compounds with anticancer properties. This feature is primarily attributed to polysaccharides and their derivatives. The anticancer potential of polysaccharides is linked to their origin, composition and chemical structure, solubility and method of isolation. Moreover, their activity can be significantly increased by che...

We have recently reported that the intravaginal instillation of synthetic Toll-like receptor 3 (TLR3) or TLR9 agonists after a subcutaneous vaccination against human papillomavirus E7 highly increases (~5-fold) the number of vaccine-specific CD8+ T cells in the genital mucosa of mice, without affecting E7-specific systemic responses. Here, we show that the instillation of live attenuated Salmon...

Female mice of inbred strain CBA do not reject syngeneic male skin grafts even though they mount a T-cell response against the male-specific HY antigen. We show that local immunostimulation performed by injecting cytokines and Toll-like receptor ligands in close vicinity to the graft causes rejection. We feel that this approach should be tested in tumor-bearing human patients in combination wit...

Sepsis is associated with failure of multiple organs, including failure of the immune system. The resulting 'sepsis-associated immunosuppression' resembles a state of immunological anergy that is characterized by repeated 'infectious hits', prolonged multiple-organ failure, and death. As a consequence, adjunctive treatment approaches using measures of immunostimulation with colony-stimulating f...

Administration of herbal preparation, Rasayanas has been found to enhance the natural killer cell activity in normal as well asin tumour bearing animals. Brahma Rasayana (BR) was found to have the maximum activity. BRand Aswagandha Rasayana (AR) were found to activate antibody-dependent cellular cytotoxicity significantly. AR was also found to activate macrophages. All the Rasayanas were found ...

Conflicts of interest C.A.M. has acted as an invited speaker for Galderma (specific), Astellas (nonspecific), Almirall (nonspecific) and LEO Pharma (nonspecific); has received sponsorship to attend conferences from LEO Pharma (nonspecific); and has participated in the advisory boards of Almirall, Astellas and LEO Pharma (nonspecific). D.J.E. has participated in the advisory board of, and receiv...

introduction: low back pain is the most common musculoskeletal complication. although there are many ways to treat low back pain, achieving a concise, simple, and compact method is required in today's industrial societies. the purpose of this study was to evaluate the effect of six weeks selected core stabilization exercises on pain and functional disability in patients with nonspecific chronic...

background: sociodemographic characteristics of nurses who work in hospitals may impact on their quality of life. this study aimed to assess the relationship between quality of life of nursing staff with chronic nonspecific low back and their sociodemographic characteristics.   materials and methods: this study was a cross section study. a total of 119 nurses were participated in this study. th...