Acute mountain sickness (AMS) strikes those in the mountains who go too high too fast. Although AMS has been long assumed to be due solely to the hypoxia of high altitude, recent evidence suggests that hypobaria may also make a significant contribution to the pathophysiology of AMS. We studied nine healthy men exposed to simulated altitude, normobaric hypoxia, and normoxic hypobaria in an envir...

BACKGROUND Exercise induced cardiac fatigue has recently been observed after prolonged exercise. A moderate to high altitude has been suggested as a possible stimulus in the genesis of such cardiac fatigue. OBJECTIVE To investigate if exercise induced cardiac fatigue and or cardiac damage occurs after prolonged exercise in a hypoxic environment. METHODS Eight trained male triathletes volunt...

In order to study the interaction of glutathione, vitamin C and vitamin E under hyperoxia (95 % oxygen) and hyperbaric oxygen (2.5 atmospheric pressure), 20 days old male Guinea pigs were fed with basal vitamin C free diet, while receiving a vitamin C supplement of either high concentration (50 mg/day) or low concentration (1 mg/day) for two weeks. Animals were than exposed to hyperoxia and hyp...

Objective: to identify the association of hyperoxia at time Intensive Care Unit (ICU) admission with clinical outcomes in adult patients on invasive mechanical ventilation and respiratory dysfunction defined by a PaO2/FIO2 ratio (P/F) below 300. Methods: retrospective cohort observational study data from admitted general ICU, 8 beds university hospital. Hyperoxia was as PaO2 > 120mmHg were c...

Bronchopulmonary dysplasia (BPD) is one of the main causes chronic lung disease in premature infants. Acute injury following exposure to hyperoxia contributes development BPD preterm The nuclear factor‑erythroid 2‑related factor 2 (Nrf2) signaling pathway an endogenous antioxidant defense mechanism that involved pathogenesis numerous hyperoxia‑induced diseases. In present study, expression Nrf2...

Five-week-old normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were subjected to hyperbaric oxygenation with an enhanced atmospheric pressure (950 mmHg) and an increased oxygen concentration (36%) for 6 h per day. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were monitored for 8 weeks of hyperbaric oxygenation period. After 8 weeks of hyperbaric...

Abstract Background Hyperoxia downregulates the tight junction (TJ) proteins of alveolar epithelium and leads to barrier dysfunction. Previous study has showed that STE20/SPS1-related proline/alanine-rich kinase (SPAK) interferes with intestinal function in mice. The aim present is explore association between SPAK after hyperoxic exposure. Methods Hyperoxic acute lung injury (HALI) was induced ...