Spectrophotometric and electrochemical studies were successfully used in quantitative analysis of Amitriptyline Hydrochloride (ATH) and Nortriptyline Hydrochloride (NTH). Conductometric titration were carried out in equeous solution using iodide and dopamine and serotonine as titrant. Two new methods using spectrophotometry are dascribed for the determination of (ATH) and (NTH) with potassium b...

Abstract This is a case report highlighting the side effect of suicidal ideation with lemborexant, novel agent approved for treatment insomnia. A 22-year-old man received care at an outpatient psychiatrist major depressive disorder, persistent generalized anxiety social phobia, and The patient also has diagnosis Loeys-Dietz syndrome, connective tissue disorder. Following numerous medication tri...

Introduction Tricyclic antidepressants (TCAs) have an important role in pharmacotherapy of Major Depressive Disorder (MDD). TCA dosing is aimed at achieving a concentration the therapeutic window. Due to inter-individual differences activity Cytochrome P450 (CYP) 2D6 and 2C19, (enzymes involved metabolism) patients require individualized dose. Currently, finding suitable dosage process trial-an...

Postherpetic neuralgia (PHN) is a chronic neuropathic pain condition that lasts 3 months or more after an outbreak of shingles. Herpes zoster, especially acute herpes associated with the reactivation inactivated varicella zoster virus in individuals who have had chickenpox. PHN persistent and often refractory pain. Patients may experience several types pain, including deep intolerable burning, ...

AIM The role of the Serotonin receptor 5HT2A and Serotonin transporter 5HTTLPR polymorphisms was suggested in the pathogenesis of depression and the therapeutic response to serotonergic drugs. The aim of this study was to find a possible association between polymorphisms of ins/del in the 5-HTT gene and T102C in the 5HTR2A gene and drug response for escitalopram and nortriptyline in depressed p...