We show that there is no (1 + ε)-approximation algorithm for the problem of covering points in the plane by minimum number of fat triangles of similar size (with the minimum angle of the triangles being close to 45 degrees). Here, the available triangles are prespecified in advance. Since a constant factor approximation algorithm is known for this problem [CV07], this settles the approximabilit...

The present work introduces a computational model, the Parallel Episodic Processing (PEP) model, which demonstrates that contingency learning achieved via simple storage and retrieval of episodic memories can explain the item-specific proportion congruency effect in the colourword Stroop paradigm. The current work also presents a new experimental procedure to more directly dissociate contingenc...

I am sure you’ve heard about the triple aim introduced by the Institute for Healthcare Improvement —improving patient experience, reducing cost, and improving the health of a population. I recently discovered that this is being reconsidered, in light of a crucial missing piece – the people who actually are responsible for the patient experience and healthcare. Now conceptualized as the quadrupl...

many who have been studying artistic products and the creative impulse that no glib formula can be stated on the basis of a superficial examination, even though of hundreds of free drawings. Joanna Field gives an answer to those who are constantly criticizing psychoanalysis for lack of integrative functions or any philosophic approach to life. She has for the first time, as far as I know, put i...

Rossana Taravella, Marco Caruso, Massimo Benedetto, Renato Ciofalo, Giuliana Pace, Salvatore Asciutto, Salvatore Novo, Giuseppe Cirrincione Division of Interventional Cardiology, Arnas Civico Hospital. Division of Cardiology, University Hospital “Policlinico P. Giaccone”, Palermo, Italy Division of Interventional Cardiology, Arnas Civico Hospital, Palermo, Italy Division of Cardiology, Universi...

Drugs acting at G-protein coupled receptors (GPCRs) represent the core of modern medicine. Traditionally, these drugs target the orthosteric site of the receptors, i.e. the binding site of the endogenous agonist. An increasing number of patents describe synthetic allosteric modulators of GPCRs, which influence receptor activity at sites distinct from the orthosteric site. This documents that th...