نتایج جستجو برای: nr1 receptor
تعداد نتایج: 590604 فیلتر نتایج به سال:
BACKGROUND A severe form of encephalitis associated with antibodies against NR1-NR2 heteromers of the NMDA receptor was recently identified. We aimed to analyse the clinical and immunological features of patients with the disorder and examine the effects of antibodies against NMDA receptors in neuronal cultures. METHODS We describe the clinical characteristics of 100 patients with encephaliti...
Agricultural practices such as fertilization considerably influence soil greenhouse gas fluxes. However, the effects of on gases fluxes remain unclear in tea when nitrogen is low. In present study, CO2 and CH4 under various treatments were investigated during a 50-day period. The experiment consisted five treatments: no fertilizer (CK), single (urea, N), oilseed rape cake (R), + (2:1, NR1), (1:...
Although the trafficking of AMPA receptors has received much recent fanfare as a mechanism for synaptic plasticity, NMDA receptors have received less attention in this regard. However, Scott et al. now show that independent regions within the cytoplasmic domains of NMDA receptor type 1 (NR1) and NMDA receptor type 2 (NR2) subunits target NMDA receptors for internalization. Interestingly, the re...
Subunit composition of NMDA receptors (NMDARs) determines a range of physiological properties, downstream signaling effects, and binding partners. Differential localization of NR2A- or NR2B-containing NMDARs within the neuron and subunit-specific protein associations may explain differences in NR2A and NR2B contributions to synaptic plasticity and excitotoxic cell death. This question is compli...
We tested the hypothesis that primary afferent inputs play a role in astroglial hyperactivity after tissue injury. We first injected complete Freund's adjuvant (CFA, 0.05 ml, 1:1 oil/saline) into the masseter muscle, which upregulated glial fibrillary acidic protein (GFAP), a marker of astrocytes, interleukin (IL)-1β an inflammatory cytokine, and phosphorylation of serine896 of the NR1 subunit ...
SEE ZEKERIDOU AND LENNON DOI101093/AWW213 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently discovered autoimmune syndrome associated with psychosis, dyskinesias, and seizures. Little is known about the cerebrospinal fluid autoantibody repertoire. Antibodies against the NR1 subunit of the NMDAR are thought to be pathogenic; howeve...
Regulation of proteins affecting NMDA receptor-induced excitotoxicity in a Huntington's mouse model.
Symptoms of Huntington's disease may be caused by a toxic insult triggered by the mutant human huntingtin (Htt) protein itself, by a maladaptive protective mechanism initiated in response to an insult, or by a combination of these. We observed a protection from N-methyl-d-aspartate (NMDA) receptor-induced excitotoxicity in striata of symptomatic N171-82Q mice, a new transgenic model of Huntingt...
The functional enhancement of NMDA receptors after peripheral tissue injury is proposed to contribute to the sensitization of spinothalamic tract (STT) cells and hyperalgesia. Protein phosphorylation is a major mechanism for the regulation of NMDA receptor function. In this study, Western blots, immunofluorescence double labeling, and the retrograde tracing method were used to examine whether p...
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