BACKGROUND Myocardial fibrosis is common in patients with chronic aortic regurgitation (AR). Experimentally, fibrosis with disproportionate noncollagen extracellular matrix (ECM) elements precedes and contributes to heart failure in AR. METHODS AND RESULTS We assessed [3H]-glucosamine and [3H]-proline incorporation in ECM, variations in cardiac fibroblast (CF) gene expression, and synthesis o...

Background: The role of paraoxonase 1 enzyme (PON1) and its single nucleotide polymorphisms (SNPs) in children with nephrotic syndrome (NS) has been reported previously different ethnic racial groups divergent results. human PON1 gene contains two coding region leading to isoforms. Objectives: aim the present study was find out association between (Q192R L55M) their relation serum activity as w...

Objective To evaluate the early and late effects of N-acetyl-l-cysteine (NAC) treatment on renal ischemia reperfusion (I/R) insult in adult Wistar rats influenced by chronic high sodium (HS) intake. Methods Adult male (8 weeks age) received an HS (8.0% NaCl) or normal (NS; 1.3% diet NAC (600 mg/L) drinking water water. At 11 age, underwent a I/R procedure. They followed for 10 after I/R, at 1st...

Noonan Syndrome (NS) is an autosomal dominant disorder in which parents with syndrome have a 50percent chance of passing the mutation to their children, most commonly due PTPN11 gene. In clinical case, we identified male child who showed features such as short stature, congenital heart disease and peculiar facial appearance, strongly suspecting syndrome. The purpose this article report presenta...

Several malignant tumor cells become apoptotic and revert to the benign phenotype upon parvovirus infection. Recently, we demonstrated that the rat parvovirus RPV/UT also induces apoptosis in the rat thymic lymphoma cell line C58(NT)D. However, a minority of cells that escaped apoptosis showed properties different from the parental cells, such as resistance to apoptosis, enhanced cell adherence...