Background: This report describes the study design and baseline characteristics of patients with Stargardt disease (STGD1) enrolled in STArgardt Remofuscin Treatment Trial (STARTT). Methods: In total, 87 genetically confirmed STGD1 were randomized a double-masked, placebo-controlled proof concept trial to evaluate safety efficacy 2...

Background: Evidence of highly effective repurposed drugs for coronavirus disease 2019 (COVID-19) is insufficient. However, empirical therapy using antiviral, antibiotic and immunomodulatory massive. This study aimed to evaluate the clinical use these outcome hospitalization in COVID-19 patients. Methods: We performed a retrospecti...

Background: Sugar substitutes like maltitol are reported to be noncariogenic ingredients and may not lead the development of dental caries (DC), in contrast sugars other fermentable carbohydrates. The current study aimed investigate effects maltitol-based sugar-free chocolates on factors associated with DC. Methods: This was an ope...

Background: This study was conducted to determine the prevalence of headache in coronavirus disease 2019 (COVID-19) and assess its association as a predictor for COVID-19. also aimed discuss possible pathogenesis COVID-19. Methods: Available articles from PubMed, Scopus, Web Science were searched September 2nd, 2...

The cytotoxicity of Ibaraki virus nonstructural protein NS3 was confirmed, and the contribution of glycosylation to this activity was examined by using glycosylation mutants of NS3 generated by site-directed mutagenesis. The expression of NS3 resulted in leakage of lactate dehydrogenase to the culture supernatant, suggesting the cytotoxicity of this protein. The lack of glycosylation impaired t...

Abstract Background Youth have disproportionately poor HIV outcomes. We aimed to co-design a community-based intervention with youth improve outcomes among 16-24 year-olds, be trialled in Zimbabwe. Methods conducted 90 in-depth interviews youth, family members, community gatekeepers, and hea...

Background: Virus genome sequencing is increasingly utilized in epidemiological surveillance. Genomic data allows comprehensive evaluation of underlying viral diversity and epidemiology to inform control. For human rhinovirus (HRV), genomic amplification challenging due numerous types, high genetic inadequate reference sequences. Methods:</ns...

Similar to many flavivirus types including Dengue and yellow fever viruses, the nonstructural NS3 multifunctional protein of West Nile virus (WNV) with an N-terminal serine proteinase domain and an RNA triphosphatase, an NTPase domain, and an RNA helicase in the C-terminal domain is implicated in both polyprotein processing and RNA replication and is therefore a promising drug target. To exhibi...

Background: The maintenance, regulation, and dynamics of heterochromatin in the human malaria parasite, Plasmodium falciparum, has drawn increasing attention due to its regulatory role mutually exclusive virulence gene expression silencing key developmental regulators. The advent genome-wide analyses such as chromatin-immunoprecipitation foll...

Background: To increase vaccination coverage, it is important to understand COVID-19 programs and respondents’ acceptance. Therefore, this study aimed measure knowledge of the vaccine its acceptance among Indonesian adults in Java. Methods: A web-based survey was distributed through social media on self-claimed knowledge, risk bene...