N onsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat inflammation, pain, and fever by decreasing prostaglandin synthesis through blockage of the cyclooxygenase (COX) enzyme. Table 1 lists NSAID dosages and monthly costs. There is little evidence to support differences in effectiveness for pain treatment when comparing all NSAIDs. Aspirin is used for primary and secondary pr...

Inflammation is a complex biological response and like other parts of the body, ocular inflammation could have untoward effects on vision if not detected and/or diagnosed early. NSAIDs are the major ocular therapeutics for treating such eye inflammations and preferred over corticosteroids. NSAIDs are given orally as well as topically to treat ocular inflammations, however topical route is prefe...

Evidence • Adults—2 RCTs (N = 140) of predominantly middle-aged women with Colles fractures randomized to flurbiprofen (14 days)1 or piroxicam (20 mg/d for 8 weeks)2 versus placebo: -No difference in recovery time, physiotherapy needs, malunion or nonunion,1 functional recovery, or healing.2 -Superior pain relief with NSAIDs (both trial arms allowed acetaminophen if required). -Limitations: abo...

388 Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most widely used over-the-counter (OTC) drugs worldwide. Though the extent of their usage in the Indian population is not known, it is likely to be large. Their major usage is as casual prescription for their analgesic and anti-inflammatory action, and in organized rheumatology and orthopedic practice. These drugs have also been ...

Non-steroidal anti-inflammatory drugs (NSAIDs), which act via inhibition of the cyclooxygenase (COX) isozymes, were discovered more than 100 years ago. They remain a key component of the pharmacological management of acute and chronic pain. The COX-1 and COX-2 isozymes have different biological functions; analgesic activity is primarily (although not exclusively) associated with inhibition of C...

BACKGROUND To compare the prescription modalities of general practitioners (GPs) and rheumatologists (RHs) for symptomatic knee osteoarthritis (OA) and to determine correlates with prescription of low-dose NSAIDs. METHODS This observational, prospective, national survey was carried out among a national representative sample of GPs (n = 808) and RHs (n = 134). Each physician completed a medica...