The translation of cellular mRNA to protein is a tightly controlled process often deregulated in diseases such as cancer. Furthering our understanding of mRNA structural elements and the intracellular proteins and signaling pathways that affect protein expression is crucial in the development of new therapies. In this review, we discuss the current state-of-the-art of detecting and determining ...

Closed string tachyon condensation resolves the singularities of nonsupersymmetric orbifolds, however the resolved space typically has fewer D-brane charges than that of the orbifold. The description of the tachyon condensation process via a gauged linear sigma model enables one to track the topology as one passes from the sigma model’s “orbifold phase” to its resolved, “geometric phase,” and t...

The THO complex and Sub2 RNA helicase have been shown to function in both transcription and mRNA processing. Rougemaille et al. (2008) now uncover evidence that THO/Sub2 coordinates mRNA processing and nuclear export.

Let me begin by thanking Bernard Frois and the Organizing Committee for making it possible for us to enjoy both the 1998 International Nuclear Physics Conference and the lovely city of Paris. My charge today is to summarize fundamental symmetries and theory, a topic with a rich history in nuclear physics. A generation ago nuclear studies of β decay helped established the V-A nature of the weak ...