In medical microscopy, image analysis offers to pathologist a modern tool, which can be applied to several problems in cancerology: quantification of DNA content, quantification of immunostaining, nuclear mitosis counting, characterization of tumor tissue architecture. However, these problems need an accurate and automatic segmentation. In most cases, the segmentation is concerned with the extr...

The automated diagnosis of cervical cancer in Pap smear images is a difficult though extremely important procedure. In order to obtain reliable diagnostic information, the nuclei and their characteristics must be correctly identified and evaluated. However, the presence of inflammatory and overlapping cells in these images complicates the detection process. In this work, a segmentation algorith...

Basal ganglia and brain stem nuclei are involved in the pathophysiology of various neurological and neuropsychiatric disorders. Currently available structural T1-weighted (T1w) magnetic resonance images do not provide sufficient contrast for reliable automated segmentation of various subcortical grey matter structures. We use a novel, semi-quantitative magnetization transfer (MT) imaging protoc...

In this paper, a modified segmentation algorithm for printed Farsi words is presented. This algorithm is based on a previous work by Azmi that uses the conditional labeling of the upper contour to find the segmentation points. The main objective is to improve the segmentation results for low quality prints. To achieve this, various modifications on local baseline detection, contour labeling an...

In the medical field, hematoxylin and eosin (H&E)-stained histopathology images of cell nuclei analysis represent an important measure for cancer diagnosis. The most valuable aspect is segmentation different morphologies organs subsequent diagnosis type severity disease based on pathology. recent years, deep learning techniques have been widely used in digital analysis. Automated nuclear te...

Analysis of microscopy images can provide insight into many biological processes. One particularly challenging problem is cellular nuclear segmentation in highly anisotropic and noisy 3D image data. Manually localizing and segmenting each and every cellular nucleus is very time-consuming, which remains a bottleneck in large-scale biological experiments. In this work, we present a tool for autom...

Automated nuclear segmentation is essential in the analysis of most microscopy images. This paper presents a novel concavitybased method for the separation of clusters of nuclei in binary images. A heuristic rule, based on object size, is used to infer the existence of merged regions. Concavity extrema detected along the merged-cluster boundary are used to guide the separation of overlapping re...

We propose a new way of embedding shape distributions in a topological deformable template. These distributions rely on global shape descriptors corresponding to the 3D moment invariants. In opposition to usual Fourier-like descriptors, they can be updated during deformations at a relatively low cost. The moment-based distributions are included in a framework allowing the management of several ...

In this paper, we present a novel method based on active contours for segmentation and fuzzy rule based classification of microscopic images of esophagus tissues obtained from the abnormal regions of human esophagus detected through endoscopy. This method is used for classification of Squamous Cell Carcinoma (SCC) of esophagus, namely, well differentiated (WD), moderately differentiated (MD), a...