introduction: in continuation of recent development of possible c-x-c chemokine receptor type 4 (cxcr4) imaging agents, we report the development of a possible cxcr4 targeted therapy agent. methods: [153sm]labeled 1,1′-[1,4-phenylenebis(methylene)] bis-1,4,8,11-tetraazacyclo -tetradecane ([153sm]-amd3100) was prepared using [153sm]smcl3 and amd-3100 for 24h at 50°c in acetate buffer.stability ...

Methods All subjects were prospectively recruited to undergo cardiac MRI in a 1.5 T scanner. Modified Look-Locker Inversion recovery sequence was used with motion correction included in the post processing algorithm. Pre-contrast and post contrast (20 minutes after gadolinium injection at 0.15 mmol/kg) T1 maps of the blood pool and myocardium were assessed in basal, mid and apical segments of t...

NUROMAX (doxacurium chloride) is a long-acting, nondepolarizing skeletal muscle relaxant for intravenous administration. Doxacurium chloride is [1α,2β(1'S*,2'R*)]-2,2' -[(1,4-dioxo-1,4butanediyl)bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7,8-trimethoxy-2methyl-1-[(3,4,5trimethoxyphenyl)methyl]isoquinolinium] dichloride (meso form). The molecular formula is C56H78CI2N2O16 and the molecula...

it is well known that the chemical behavior of a compound is dependent upon the structure of itsmolecules. quantitative structure – activity relationship (qsar) studies and quantitative structure –property relationship (qspr) studies are active areas of chemical research that focus on the nature ofthis dependency. topological indices are the numerical value associated with chemical constitution...

An l-sequence is defined by an = lan−1 − an−2, with initial conditions a0 = 0, a1 = 1. These l-sequences play a remarkable role in partition theory, allowing l-generalizations of the Lecture Hall Theorem [7, 8] and Euler’s Partition Theorem [8, 26]. These special properties are not shared with other sequences, such as the Fibonacci sequence, defined by second-order linear recurrences. The l-seq...

This work presents the abilities in estimation and prediction of the octanol–water partition coefficient of some para-substituted phenols through the integration of complex structures information by the use of an original molecular descriptors family on the structure–property relationship approach. The proposed approach uses the complex information obtained from para-substituted phenols structu...

An assessment was made of the in situ bioaccumulation of 13 polycyclic aromatic hydrocarbons (PAHs) in freshwater isopods in relation to their partitioning between sediments, particulate matter (>0.7 µm), and dissolved phases in eight different water systems of The Netherlands. Large differences in total (Gamma PAHs) concentrations and in relative abundance of individual PAHs were observed betw...

BACKGROUND Contrast enhanced cardiovascular magnetic resonance (CMR) with T1 mapping enables quantification of diffuse myocardial fibrosis. Various factors, however, can interfere with T1 measurements. The purpose of the current study was to assess the effect of co-medication with a typical protein binding drug (ibuprofen) on T1 values in vitro and in vivo. METHODS 50 vials were prepared with...

1. Introducing the birank. A partition is defined as being a nonincreasing sequence of positive integers, λ = (λ1,λ2, . . . ,λr ). The set of all partitions, which includes the empty partition ∅, is denoted by . The sum of the parts of a given partition is called the weight of the partition, wt(λ) = λ1+λ2+···+λr . It is standard notation to write (z;q)∞ := ∏ t≥0(1−zq) and p−k(n) for the coeffic...

Chloroform, bromodichloromethane, chlorodibromomethane, and bromoform comprise the trihalomethanes, a group of widespread and mildly lipophilic compounds that result from water chlorination and other sources. Many animal studies show the chronic toxicity and carcinogenicity of these compounds, and recent work has demonstrated the importance of both ingestion and inhalation exposure pathways. Th...