Uveitis can be a sight-threatening eye disease with significant morbidity. Corticosteroids remain the mainstay of treatment of uveitis and provide an effective treatment against ocular inflammation. However, the various modes available for corticosteroid drug delivery can carry significant ocular and systemic side effects which can limit their use in the treatment of uveitis. In an effort to av...

Drug delivery carriers can maintain effective therapeutic concentrations in the eye. To this end, we developed lipid nanoparticles (L/NPs) in which the surface was modified with positively charged chitosan, which engaged in hydrogen bonding with the phospholipid membrane. We evaluated in vitro corneal permeability and release characteristics, ocular irritation, and drug dynamics of modified and...

Ocular Drug Delivery has been a key challenge and attractive field for the pharmaceutical scientist due to peerless anatomy physiology of eye. Glaucoma, dry eye syndrome, keratitis, endophthalmitis, trachoma, conjunctivitis are just few conditions that can affect In order accomplish efficient ocular treatment within eye, At point action, an appropriate supply active substances must be given sus...

Ocular drug delivery is one of the most fascinating and challenging endeavours facing the research world of pharmaceutics. The poor uptake of many ocular drugs is mainly due to the rapid elimination process by tear turnover. A prolonged precorneal residence time would result in higher absorption for some drugs, a prolonged duration of their therapeutic effect. Recently, in-situ gel formulations...

The eye is a highly sensitive organ. Its physiology and anatomy leads to considering it as a highly protected organ. Effective therapy depends on designing of delivery system. Brain targeting through the ocular delivering system, is a formidable task. But now a day’s ocular delivery plays a promising approach towards brain targeting. The Scientist has been found, some alternative models for bra...