The spinocerebellar ataxia recessive type 10 is a genetic form associated with ANO10 gene mutations. Affected individuals present ataxia, hyperreflexia, ocular movement disorders and cerebellar atrophy. homozygous variant in the NP_060545.3:p.Asn114* 2-nucleotide deletion that would cause introduction of premature stop codon at same position, has not been previously described scientific literat...

Vertigo, instability, dizziness, or equilibrium disorders are not usually considered as consequences of ophthalmologic problems. We present data indicating that ocular disorders can be responsible for these symptoms in children. In a population of 523 pediatric patients with vertigo or disequilibrium and referred for vestibular testing in our otolaryngology department during a 5-year period, 27...

Anuchit Poonyathalang1 Sangeeta Khanna2 R John Leigh2 1Department of Ophthalmology, Ramathibodi Hospital, Bangkok, Thailand; 2Neurology Service, Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, Ohio, USA Abstract: Recent discoveries about the orbital tissues prompt a re-evaluation of the way that clinicians think about disorders affecting the extraocular muscles, the...

Recent discoveries about the orbital tissues prompt a re-evaluation of the way that clinicians think about disorders affecting the extraocular muscles, their nerves and motoneurons in the brainstem. The revolutionary discovery that the orbital layers of the extraocular muscles insert not onto the eyeball, but into fibromuscular pulleys that guide the orbital layers, provides explanations for th...

Obstructive sleep apnea hypopnea syndrome; Ocular complications Abstract Introduction: Sleep disorders are common and obstructive sleep apnea hypopnea syndrome (OSAHS) is the commonest. OSAHS is not commonly diagnosed by the ophthalmologist, but it has many systemic and ocular complications. Aim of the work: The aim of this study was to detect the effect of sleep related breathing disorders on ...

Monoclonal antibodies against rabbit ocular mucin (ROM) and porcine stomach mucin (PSM) were developed to explore the biosynthesis and functional significance of ocular mucin. A nitrocellulose-based dot enzyme-linked immunosorbent assay (ELISA) was developed for hybridoma screening and mucin quantitation. The sensitivity was found to be at the level of 1 ng mucin per dot, which was about 1000 t...

Uveitis describes a variety of patterns of intraocular inflammation that may be linked with other localised ocular and orbital inflammations as well as extraocular disease. Expermental models of autimmune uveitis fail to reflect not only the clinical variety of ocular inflammatory disease but also the marked differences in pathology of human multi-system diseases that often result in very simil...

BACKGROUND Although around 70% of HIV+ cases used to have ocular manifestations, the late reporting of cases often results in severe forms of ocular morbidity that would otherwise have been prevented. The objective of this study was to describe the ocular manifestations of HIV and AIDS-related patients who had been admitted to TM Jafferji Hospital, Dar-es-Salaam, Tanzania. METHODS Proven case...

Background Neuro-ophthalmic emergencies are relatively uncommon, however their outcome cause severe morbidity and even mortality. The ocular manifestations of these disorders are pointers to a more dangerous central nervous system or systemic pathology. The review aims to highlight the major ocular disorders that constitute neuro-ophthalmologic emergencies with a view to increasing the index of...