PURPOSE To investigate the combined effect of olfactory ensheathing cell (OEC) transplantation and recombinant human glial cell line-derived neurotrophic factor (rhGDNF) intravitreal injection on optic nerve functional recovery following incomplete injury in adult rats. METHODS The optic nerves of adult rats were crushed by forceps and then GDNF was injected into vitreous cavity, OECs transpl...

WO3 is a promising candidate for a photoanode material in an acidic electrolyte, in which it is more stable than most metal oxides, but kinetic limitations combined with the large driving force available in the WO3 valence band for water oxidation make competing reactions such as the oxidation of the acid counterion a more favorable reaction. The incorporation of an oxygen evolving catalyst (OE...

Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths worldwide with significant unmet medical need. MYC over-expression associated aggressive disease in up to ∼70% HCC. While represents an attractive therapeutic target, it has historically been considered undruggable, due lack structured binding pocket and tightly regulated expression. The gene its regulatory elements are part ins...

BACKGROUND Endothelial progenitor cells (EPCs) are implicated in protection against vascular disease. However, studies using angiography alone have reported conflicting results when relating EPCs to epicardial coronary artery disease (CAD) severity. Moreover, the relationship between different EPC types and the coronary microcirculation is unknown. We therefore investigated the relationship bet...

OBJECT The results of olfactory ensheathing cell (OEC) transplantation have raised great expectations as a potential treatment for spinal cord injury (SCI). Its capacity to promote functional neural repair, however, remains unclear. The authors studied axonal growth and locomotor recovery after C-7 contusion injury and OEC transplantation in adult rats. METHODS Twenty-four male Wistar rats un...

The successful vascularisation of complex tissue engineered constructs for bone regeneration is still a major challenge in the field of tissue engineering. In this context, co-culture systems of endothelial cells and osteoblasts represent a promising approach to advance the formation of a stable vasculature as well as an excellent in vitro model to identify factors that positively influence bon...

We study two families of four-photon superpositions the Fock states: even vacuum squeezed states (EVSS) and orthogonal-even coherent (OECS). These are distinguished due to several properties: for certain values parameters, they give fourth-order uncertainty products close known minimal value (which is lower than Gaussian states); have equal dimensionless second- fouth-order moments coordinate m...

This research aims to analyse the evolution of "online epistemic communities" (OECs), focussing on the collective processes of article elaboration in Wikipedia. It responds to the important yet still open challenge in Cognitive Ergonomics of constructing methods for analysing/ensuring the quality of collective products, in relation to both their intrinsic characteristics (e.g. completeness, rea...

Neurotrauma injuries are notoriously difficult to deal with both clinically as well experimentally, the cellular and molecular events ensuing after injury complicate neuroinflammatory processes. Spinal cord further complicated by formation of scars at sites, which can provide a physical barrier repair. The lack effective clinical therapy for spinal underscores need experimental approaches gener...