Anaemia is common in a wide range of malignancies and individual studies have demonstrated it to be an independent prognostic marker for survival in certain cancer types. The study population consisted of 171 patients: 77 anaemic and 94 non-anaemic. Sixty per cent of the study population had adenocarcinoma with 37% having squamous cell carcinoma. Late-stage disease occurred in 80% of individual...

BACKGROUND Ectopic gastric mucosa (EGM) otherwise termed gastric heterotopia or gastric inlet patch occurs in approximately 2.5% of the population. Adenocarcinoma uncommonly involves the upper oesophagus, rarely arising from gastric heterotopia or submucosal glands. Currently, there are 58 cases in the literature of oesophageal adenocarcinoma arising within areas of EGM. To date no paper has di...

We describe a case of exudative pleural effusion in a patient with mucinous pulmonary adenocarcinoma. Pleural fluid examination showed markedly raised amylase with normal serum amylase concentration. There was no clinical or radiological evidence of oesophageal rupture or pancreatitis. The case illustrates the importance of considering pulmonary malignancy in the context of amylase-rich pleural...

BACKGROUND For oesophageal cancer there is no effective standard therapy. We studied the feasibility and efficacy of the cisplatin-gemcitabine combination chemotherapy in patients with unresectable oesophageal cancer. PATIENTS AND METHODS Thirty-six chemonaïve patients with unresectable or metastatic oesophageal adenocarcinoma (24) or squamous-cell-carcinoma (12) were treated with cisplatin (...

The report by WCRF / AICR (2007) concluded that high intake of processed meat convincingly increases the risk of colorectal cancer (CCR). In relation to esophageal (EA) and gastric cancer (GC) the report judged evidence as limited-suggestive. Previous results from EPIC have shown that processed meat PM is a risk factor for CCR (Norat, JNCI, 2005) and GC (González, JNCI 2006). Moreover, a prelim...

Corrigendum: A comparative analysis of whole genome sequencing of esophageal adenocarcinoma preand post-chemotherapy Ayesha Noorani, Jan Bornschein, Andy G. Lynch, Maria Secrier, Achilleas Achilleos, Matthew Eldridge, Lawrence Bower, Jamie M.J. Weaver, Jason Crawte, Chin-Ann Ong, Nicholas Shannon, Shona MacRae, Nicola Grehan, Barbara Nutzinger, Maria O’Donovan, Richard Hardwick, Simon Tavaré, R...

Introduction: The incidence of oesophageal adenocarcinoma (OAC) has increased dramatically over recent years and Barrett's oesophagus (BO) is the most established risk factor for its development. Endoscopic surveillance of BO has been widely advocated but hinges on assessment of repeated endoscopic biopsies, which is problematic. The use of biomarkers presents an opportunity to reduce sampling ...