Despite significant improvement over recent decades, oesophageal cancer survival rates remain poor. Neoadjuvant chemoradiotherapy followed by oesophageal resection is mainstay of therapy for resectable oesophageal tumours. Operative morbidity and mortality associated with oesophagectomy remain high and complications arise in up to 60% of patients. Management strategies have moved towards defini...

BACKGROUND This study examined the interaction between natural history, current practice patterns in diagnosis, monitoring and treatment of oesophageal cancer, and associated health resource utilization and costs. METHODS A cost analysis of a prospective population-based cohort of 1100 patients with a primary diagnosis of oesophageal cancer was performed using chart review from the Australian...

Diagnosis of oesophageal cancer is usually made at endoscopic biopsy. Imaging is used to stage the tumour, assess response to therapy, and detect complications of therapy and recurrence. For therapy planning, differentiation of resectable (T1-T3, N0, localised N1) versus irresectable disease (T4, extensive N1, M1) is important. Endoscopic ultrasound (EUS) is the method of choice for diagnosing ...

BACKGROUND For rectal carcinoma, the presence of tumour within 1 mm of the circumferential margin is an important independent prognostic factor for both local recurrence and survival. Similar prospective data have not been reported for oesophageal carcinoma and we wished to ascertain the prognostic importance of this variable following potentially curative resection for oesophageal carcinoma. ...

OBJECTIVES Accurate staging of oesophageal cancer (OC) is vital. Bibliometric analysis highlights key topics and publications that have shaped understanding of a subject. The 100 most cited articles investigating radiological staging of OC are identified. METHODS The Thomas Reuters Web of Science database with search terms including "CT, PET, EUS, oesophageal and gastro-oesophageal junction c...

Despite low postoperative mortality rates, the long-term outcomes from surgical-based treatment for oesophageal cancer remain poor. Neoadjuvant (NA) Chemoradiotherapy (CRT) or chemotherapy has both been used to improve these outcomes. The optimal NA approach is yet to be defined through high quality evidence and remains the preference of individual clinicians. The evidence for neoadjuvant treat...

BACKGROUND Alarm symptom presentations are predictive of cancer diagnosis but may also be associated with cancer survival. AIM To evaluate diagnostic time intervals, and consultation patterns after presentation with alarm symptoms, and their association with cancer diagnosis and survival. DESIGN AND SETTING Cohort study using the Clinical Practice Research Database, with linked Cancer Regis...

BACKGROUND There is a paucity of published data regarding upper gastrointestinal diseases in Ugandans with upper gastrointestinal symptoms referred for endoscopy. OBJECTIVES To study the presenting complaints, pathology and Helicobacter pylori prevalence among patients with upper gastrointestinal symptoms in South-Western Uganda. METHODS Patients presenting with upper gastrointestinal sympt...

Alcohol consumption is a significant risk factor for gastrointestinal cancers that may be controlled. The of cancer increases with the amount and duration drinking. Even occasional drinking can raise risk; 100 g or less per week presently thought to upper limit low-risk consumption. causally linked colorectal cancer, hepatocellular carcinoma, gastric oesophageal squamous cell most likely also p...