Postnatal hypoxia is a main cause of neuronal damage in newborn. However, our understanding of the possible preventive or therapeutic methods to reduce the harmful effects of hypoxia is still primary. Pregnant rats were provided with running wheels during their pregnancy. On PND4 (postnatal day 4)to PND8, the rat pups were exposed to postnatal chronic hypoxia (11% O(2), 89% N(2)) in an air-tigh...

The long-lasting effects of gestational cannabinoids exposure on the adult brain of the offspring are still controversial. It has already been shown that pre- or perinatal cannabinoids exposure induces learning and memory disruption in rat adult offspring, associated with permanent alterations of cortical glutamatergic neurotransmission and cognitive deficits. In the present study, the risk of ...

22 Introduction/Purpose. Exercise improves health but few data are available regarding benefits of 23 exercise in offspring exposed to developmental programming. There is currently a worldwide 24 epidemic of obesity. Obesity in pregnant women predisposes offspring to obesity. Maternal 25 obesity has well documented effects on offspring reproduction. Few studies address ability of 26 offspring e...

Maternal exposures to environmental factors during pregnancy influence the risk of many chronic adult-onset diseases in the offspring. Here we investigate whether feeding pregnant rats a high-fat (HF)- or ethinyl-oestradiol (EE2)-supplemented diet affects carcinogen-induced mammary cancer risk in daughters, granddaughters and great-granddaughters. We show that mammary tumourigenesis is higher i...

This study examined the effects of maternal ethanol (EtOH) consumption during pregnancy or lactation on glucose homeostasis in the adult rat offspring. Glucose disposal was determined by minimal model during an intravenous glucose tolerance test in rats that had a small or normal birth weight after EtOH exposure in utero and in rats whose mothers were given EtOH during lactation only. All three...

Background & Aims: Today, due to the modern industrial life of human beings, stress has become prevalent among them and they will suffer from its complications. Exposure to stress during pregnancy can change many babies' normal physiological processes. The separate and combined effects of three common types of prenatal stress were investigated on motor learning of male offspring of rats. Method...

There is growing evidence of transgenerational effects a single exposure to chemicals, whose mechanism implicated be epigenetic. However, it largely unknown whether psychiatric diseases such as ADHD or autism caused by environmental chemicals might transmitted. Rotenone (3 mg/kg), dopaminergic toxin was orally exposed Wistar male pups at 5-day old. Their spontaneous motor activity higher 1.3 fo...

Transcriptional activation of the testis-specific histone H1t gene occurs in pachytene primary spermatocytes during spermatogenesis. Specific binding of testis nuclear proteins to a rat histone H1t promoter sequence, designated the H1t/TE element, correlates with the onset of transcription. This element, located between the H1t/AC box and the H1t/CCAAT box, contains inverted repeats of a shorte...