Abstract Low-grade gliomas (LGG) represent 30% of pediatric brain tumors. Their cellular origins are unknown but presumed to arise from subtle alterations progenitor cell cycle regulation during development. Rearrangements activating MYB and MYBL1 have been identified as drivers LGG in angiocentric glioma diffuse astrocytomas, respectively, the roles these genes normal development poorly unders...

Abstract BACKGROUND Minocycline blocks microglial TNF signaling and downstream NF-κB activation, which reduces the mesenchymal phenotype in preclinical models of GBM. Primary analysis D-TERMINED trial identified a maximal tolerated dose (MTD) oral minocycline at 150 mg BID combination with temozolomide radiation. In overall population, secondary objective improved PFS was not met. Here, respons...

While oligodendrocyte precursors have previously been localized to the ventral midline, two papers in this issue of Neuron (Cai et al. and Vallstedt et al.) provide compelling evidence for a second dorsal origin of oligodendrocyte precursors in the spinal cord and hindbrain. These cells share expression of the PDGFalpha receptor and Olig2 with their ventral counterparts but differ in the requir...