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A series of clinical studies on the cytochrome P450 2C19 (CYP2C19) genotype and the pharmacokinetics and pharmacodynamics of three proton pump inhibitors (PPIs), omeprazole, lansoprazole and rabeprazole, have been conducted to establish the individualized pharmacotherapy based on the CYP2C19 genotyping, and in the present study, the CYP2C19 genotype-dependency was more pronounced for omeprazole...

Although rare, anaphylactic reactions induced by proton pump inhibitors have been reported. The presence of cross-reactivity between different members of the group is not clear. We studied 9 patients with adverse reactions to omeprazole. Clinical symptoms appeared immediately in 8 patients and after 4 hours in 1. Symptoms ranged from urticaria/angioedema in 7 cases to anaphylaxis in 2 cases. Sk...

The common side-eVects of omeprazole and other proton pump inhibitors (PPIs) are well known (ie, headache, nausea, diarrhoea, and skin rash), but there are others, which are uncommon and therefore less widely known and which may be specifically related to one member of the group. They may not be serious, but being very non-specific and relatively unknown, may tempt a clinician to look for a cau...

BACKGROUND Several studies have suggested that proton-pump inhibitors (PPIs), mostly omeprazole, interact with clopidogrel efficacy by inhibiting the formation of its active metabolite via CYP2C19 inhibition. Whether this occurs with all PPIs is a matter of debate. As rabeprazole is a less potent CYP2C19 inhibitor than other PPIs, we studied the interaction between rabeprazole and the antiplate...

BACKGROUND Medical management of GERD mainly uses proton pump inhibitors. Alginates also have proven efficacy. The aim of this trial was to compare short-term efficacy of an alginate (Gaviscon®, 4 × 10 mL/day) and omeprazole (20 mg/day) on GERD symptoms in general practice. METHODS A 14-day multicentre randomised double-blind double-dummy non-inferiority trial compared Gaviscon® (4 × 10 mL/da...

Omeprazole is a commonly prescribed drug for patients with peptic ulcerations. Its main mechanism of action is related to inhibition of H(+)-K(+)-ATP-ase, albeit it may also block carbonic anhydrase. This study evaluates the effects of acute and prolonged (3- or 7-day) intragastrical administration of omeprazole on the anticonvulsant activity of carbamazepine or diphenylhydantoin against maxima...

BACKGROUND Proton pump inhibitors (PPIs) decrease the rate of rebleeding following endoscopic hemostatic therapy in patients with bleeding peptic ulcers. This study compares the efficacy of oral omeprazole vs intravenous pantoprazole in decrease of rebleeding of peptic ulcer patients. METHODS One hundred and six patients with high risk peptic ulcer were randomized to receive either oral omepr...

Objectives: Check the progress of hospitalization and death of the patients that use clopidogrel associated with omeprazole and the patients that do not. evaluate patients that were using clopidogrel in association or not with omeprazole. Results: The study included 2823 patients. Of these patients, 36% were female and 64% were male, the mean age was 63 years. Regarding the association of drugs...