On the basis of the state–space method (SSM), a novel linear mathematical model of the unsteady flow for the tailrace system with an open channel is proposed. This novel model is an elastic linearized model of water hammer. The validity of the model has been verified by several examples of numerical simulation, which are based on a finite difference technique. Then, the complete mathematical mo...

In recent years, flash-based key-value cache systems have raised high interest in industry, such as Facebook’s McDipper and Twitter’s Fatcache. These cache systems typically use commercial SSDs to store and manage key-value cache data in flash. Such a practice, though simple, is inefficient due to the huge semantic gap between the key-value cache manager and the underlying flash devices. In thi...

Mutations in the voltage-gated sodium channel Nav1.7 are linked to inherited pain syndromes such as erythromelalgia (IEM) and paroxysmal extreme pain disorder (PEPD). PEPD mutations impair Nav1.7 fast inactivation and increase persistent currents. PEPD mutations also increase resurgent currents, which involve the voltage-dependent release of an open channel blocker. In contrast, IEM mutations, ...

N-methyl-D-aspartate (NMDA) receptors are obligate heterotetrameric ligand-gated ion channels that play critical roles in learning and memory. Here, using targeted molecular dynamics simulations, we developed an atomistic model for the gating of the GluN1/GluN2A NMDA receptor. Upon agonist binding, lobe closure of the ligand-binding domain produced outward pulling of the M3-D2 linkers, leading ...

In this paper, the electrical performance of double gate organic field effecttransistor (DG-OFET) are thoroughly investigated and feasibility of the deviceas an efficient biosensor is comprehensively assessed. The introduced deviceprovides better gate control over the channel, yielding better charge injectionproperties from source to channel and providing higher on-state...

the purpose of this paper is to present a 2d depth-averaged model for simulating and examining unsteady flow patterns in open channel bends. in particular, this paper proposes a 2d depth-averaged model that takes into account the influence of the secondary flow phenomenon through calculation of the dispersion stresses. the dispersion terms which arose from the integration of the product of the ...