OBJECTIVE Congenital heart disease (CHD) is the most common form of cardiovascular diseases in children. This study was performed from September 2006 to August 2007 in Ardebil, Westnorthern Iran. The aim was to determine the prevalence of heart murmur in newborns and its correlation with CHD. METHODS In a 1-year cross sectional descriptive-analytic study, 2928 newborns were screened for heart...

BACKGROUND Atrial septal defect often become more severe when encountered in genetic syndromes. Congenital disorder of glycosylation type 1a is an inherited metabolic disorder associated with mutations in PMM2 gene and can affect almost all organs. Cardiac abnormalities vary greatly in congenital disorder of glycosylation type 1a and congenital heart defects have already been reported, but ther...

BACKGROUND Congenital heart defects (CHD) are the most prevalent group of structural abnormalities at birth and one of the main causes of infant morbidity and mortality. Studies have shown a contribution of the copy number variation in the genesis of cardiac malformations. OBJECTIVES Investigate gene copy number variation (CNV) in children with conotruncal heart defect. METHODS Multiplex li...

A short axis echocardiographic cut of the heart from the subcostal approach was used to study the atrioventricular junction in 47 infants and children with congenital heart disease and 20 with normal hearts. Examination of the diastolic openings of both atrioventricular valves was able to establish normal developments of the valves and annuli even when this was found in cases of complex congeni...

BACKGROUND A high incidence of orofacial clefts is reported in China, but no data has shown the relation between cleft types and the incidence of other defects so far. The aim of this study is to assess the incidence of congenital heart diseases and other organic defects associated with different types of orofacial clefts. METHODOLOGY AND PRINCIPAL FINDINGS All children with orofacial clefts,...

Atrial septal defect (ASD) is one of the most common congenital cardiac diseases [1]. ASD accounts for 7-10% of all congenital heart diseases in children and 30-33% in adults. Although ASD usually asymptomatic, it can lead to exercise intolerance, atrial arrhythmia, right ventricular dysfunction, and pulmonary arterial hypertension. Guidelines recommend closure of ASD if right ventricular enlar...

Infective endocarditis is an uncommon heart disease with a variable incidence, mostly related to the ever-increasing development of cardiac surgery and the longer survival of patients with congenital heart disease (CHD). Thirty-seven episodes of infective endocarditis (IE) were evaluated in 36 children (under 15 years of age) admitted to hospitals affiliated to Shiraz University of Medical ...

Background The prevalence of celiac disease (CD) is remarkably varied in Down syndrome(DS)patientscompared with other diseases.  This study aimed to assess celiac disease prevalence in Down syndrome children with and without congenital heart defects (CHD) and its comparison with controls. Materials and Methods This case-control study was performed at a single center on 132 participants in three...

Background: Congenital hypothyroidism (CH) is a prevalent disorder, which is associated with several other congenital anomalies, especially cardiac diseases. The present study aimed to determine the prevalence of congenital heart disease (CHD) in the neonates with CH.Methods: This cross-sectional study was conducted on two groups of 79 subjects to compare the type and frequency of congenital ca...