In many patients, a 'type and screen' procedure is routinely performed before surgery. However, most patients are not transfused after all. Can we predict, which surgical patients will and will not be transfused, to reduce the number of these investigations? We studied 1482 consecutive surgical patients with intermediate risk for transfusion. Multivariate logistic regression modelling and the a...

The diagnosis of hypersensitivity pneumonitis (HP) is difficult and often relies on histopathology. Our objective was to identify diagnostic criteria and to develop a clinical prediction rule for this disease. Consecutive patients presenting a condition for which HP was considered in the differential diagnosis underwent a program of simple standardized diagnostic procedures. High-resolution com...

BACKGROUND Sinonasal complications are common in children with cystic fibrosis (CF). Generally, those children with persistent symptoms of sinonasal polyposis are referred to an otorhinolaryngologic (ORL) physician for sinus surgery. Several studies have reported differences in clinical characteristics between CF patients with and without sinonasal polyps. OBJECTIVES To predict the presence o...

Credit scoring is a classification problem leading to introducing numeroustechniques to deal with itsuch as support vector machines, neural networks and rule-based classifiers. Rule bases are the top priority in credit decision making because of their ability to explicitly distinguish between good and bad applicants. In a creditscoring context, imbalanced data sets frequently occur as the numbe...

Receiver Operating Characteristic (ROC) analysis is one of the most widely used methods for summarizing intrinsic properties of a diagnostic system, and is often used in evaluation and comparison of diagnostic technologies, practices or systems. These methods play an important role in public health since they enable researchers to achieve a greater insight into the properties of diagnostic test...

In this study, physicochemical properties of 49 compounds extracted from anti-inflammatory sponge species with the aim of ADMET test and Lipinski rule of five have been determined. Fourteen compounds, which showed best results, were subjected to molecular docking studies with IL-17. Among these compounds, Four compounds with low binding energy were obtained. These compounds, namely, frondosins ...

Background: Gestational diabetes mellitus (GDM) is one of the most common metabolic disorders in pregnancy, which is associated with serious complications. In the event of early diagnosis of this disease, some of the maternal and fetal complications can be prevented. The aim of this study was to early predict gestational diabetes mellitus by two statistical models including artificial neural ne...

This paper introduces a new method for solving the parameterization problem of the Bézier curve of a certain degree that approximates a given collection of data points. Our method is based on a discrete based-on-rules local search metaheuristic approach for optimization problems. The method is applied to some simple yet illustrative examples for the cases of 2D and 3D curves. Our experimental r...

OBJECTIVES To evaluate the responsiveness of generic and mapped preference-based measures based on the anchor of global change in health condition of colorectal cancer (CRC) patients. STUDY DESIGN AND SETTING A baseline sample of 333 Chinese CRC patients was recruited between September 2009 and July 2010 and was surveyed prospectively at 6-month follow-up. Preference-based indices were derive...

The receiver operating characteristic (ROC) curve displays the capacity of a marker or diagnostic test to discriminate between two groups of subjects, cases versus controls. We present a comprehensive suite of Stata commands for performing ROC analysis. Non-parametric, semiparametric and parametric estimators are calculated. Comparisons between curves are based on the area or partial area under...